Nucleolar Organizer Regions in Cultured Brain Tumor Cells

  • Tetsuya Shiraishi
  • Kazuo Tabuchi
  • Toshihiro Mineta
  • Nobuaki Momozaki
  • Masashi Takagi
  • Keith L. Black


Nucleolar organizer regions (NORs), segments of ribosomal DNA (rDNA) which transcribe to ribosomal RNA (rRNA), contribute to the regulation of cellular protein synthesis [1]. Since NORs-associated proteins are argyrophilic, recent modification of a silver staining technique makes it possible for NORs to be visualized (AgNORs) in chromosomal preparations and conventional paraffin sections [2]. We have proposed that the number and size of AgNORs correlate with cellular activity in general and may be indicators of the degree of proliferative potential or malignancy of human brain tumors [3,4].


Nucleolar Organizer Region Acrocentric Chromosome Human Brain Tumor Fibrillar Center Silver Staining Technique 
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Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Tetsuya Shiraishi
    • 1
  • Kazuo Tabuchi
    • 1
  • Toshihiro Mineta
    • 1
  • Nobuaki Momozaki
    • 1
  • Masashi Takagi
    • 1
  • Keith L. Black
    • 2
  1. 1.Department of NeurosurgerySaga Medical SchoolJapan
  2. 2.Division of NeurosurgeryUniversity of California at Los Angeles, School of MedicineLos AngelesUSA

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