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Novel photoreactive surface process technology for fabricated devices

  • Takehisa Matsuda
  • Kazuhiko Inoue
  • Takashi Sugawara
  • Tetsuzo Akutsu
Conference paper

Summary

A novel surface process technology was developed especially for improvement of the biocompatibility of fabricated devices such as artificial blood pumps. The principle of the technology developed is based on photochemistry of the phenyl azide group, which is capable of covalently binding a synthetic polymer or protein to substrate surfaces upon ultraviolet (UV) irradiation. The photoreactive copolymers or proteins which were grafted or modified with phenyl azide groups were prepared and successfully fixed chemically to surfaces. Photoreactive, hydrophilic copolymers such as poly (dimethyl acrylamide) and albumin, both of which were chemically fixed on surfaces, were found to be effective for blood-compatible surfaces, whereas a fibronectin-bound surface was suited for providing tissue-compatibility. The quartz optical fiberguided UV irradiation system provided the desired biocompatibility at any given part of a fabricated device.

Keywords

Peel Test Valve Ring Tissue Compatibility Styrene Sulfonic Acid Phenyl Azide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Matsuda T, Inoue K, Akutsu, T (1990) Novel surface process technology for fabricated devices. Artif Organs 14:193–195Google Scholar
  2. 2.
    Inoue K, Matsuda T (1989) (in Japanese). Polymer Preprints 36:541–544Google Scholar

Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Takehisa Matsuda
  • Kazuhiko Inoue
  • Takashi Sugawara
  • Tetsuzo Akutsu
    • 1
  1. 1.Department of BioengineeringNational Cardiovascular Center Research InstituteSuita, Osaka, 565Japan

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