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Human blood protein and cell interactions with cardiovascular materials

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Artificial Heart 3

Summary

We have investigated the interaction between blood proteins and cells with clinically used cardiovascular materials and NHLBI-DTB reference materials. These studies have determined that blood proteins adsorb to the surfaces of materials as detected by immunologic methods using radioimmunoassay or immunogold labelling. Protein adsorption occurred to a greater extent on materials without the use of anticoagulant. When polymers were coated with protein, monocytes adhered and became activated. This activation resulted in the production of growth factors for thymocytes and fibroblasts. Furthermore, the respiratory burst of monocytes with superoxide anion release was modulated by polymers. These studies suggest that the initial interaction of proteins, cells and polymers is a complex situation and that the use of cardiovascular materials must consider these important interactions.

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Author information

Authors and Affiliations

  1. Departments of Pathology, Case Western Reserve University, Cleveland, OH, 44106, USA

    James M. Anderson, Nicholas P. Ziats, Tracey L. Bonfield, Amy K. McNally & Neal S. Topham

  2. Departments of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA

    James M. Anderson

  3. Departments of Macromolecular Science, Case Western Reserve University, Cleveland, OH, 44106, USA

    James M. Anderson

Authors
  1. James M. Anderson
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  2. Nicholas P. Ziats
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  3. Tracey L. Bonfield
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  4. Amy K. McNally
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  5. Neal S. Topham
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Editor information

Editors and Affiliations

  1. Terumo Research and Development Center, 1500 Inokuchi, Nakai, Ashigarakami, Kanagawa, 259-01, Japan

    Tetsuzo Akutsu M.D., Ph.D. (Director) (Director)

  2. Department of Cardiovascular Surgery, The Heart Institute of Japan, Tokyo Women’s Medical College, 8-1 Kawadacho, Shinjuku-ku, Tokyo, 162, Japan

    Hitoshi Koyanagi M.D. (Professor and Chairman) (Professor and Chairman)

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© 1991 Springer-Verlag Tokyo

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Anderson, J.M., Ziats, N.P., Bonfield, T.L., McNally, A.K., Topham, N.S. (1991). Human blood protein and cell interactions with cardiovascular materials. In: Akutsu, T., et al. Artificial Heart 3. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68126-7_6

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  • DOI: https://doi.org/10.1007/978-4-431-68126-7_6

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68128-1

  • Online ISBN: 978-4-431-68126-7

  • eBook Packages: Springer Book Archive

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