Cardiac transplantation in the United States of America

  • Lawrence H. Cohn
  • Gilbert H. Mudge
Conference paper


Cardiac transplantation in the United States began with the experimental work by Shumway and Lower at Stanford and culminated in the performance of clinical heart transplantation at Stanford beginning in 1968 and continuing to the present. The numbers of centers in the United States have increased significantly since the general use of cyclosporin therapy began in 1984. The number of centers have increased from 35 in 1984 to over 150 in 1990. With this increase has come a decreasing number of donor hearts available per center and the number of transplants has leveled out at about 1700 per year. The number of donors has not increased substantially in the last several years as well.

The Brigham and Women’s Hospital began cardiac transplantation in 1984, and has performed 107 transplants to January 1990. The one-year survival rate is 85% and the five-year survival rate is approximately 70%.

Cardiac transplantation in the United States is a well- established procedure but the number of centers performing transplantation has escalated to the point that there is dilution of effort, both clinically and experimentally.


Heart Transplantation Cardiac Transplantation Rejection Episode Donor Heart Severe Rejection 
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  1. 1.
    Lower RR, Shumway NE (1990) Studies on orthotopic transplantation of the canine heart. Surgical Forum 11:18Google Scholar
  2. 2.
    Fragomeni LS, Kaye MD (1988) The registry of the International Society for Heart Transplantation. J Heart Transplant 7:249PubMedGoogle Scholar
  3. 3.
    Rhenman MJ, Rhenman B, Kenogle T, et al. (1988) Diabetes and heart transplantation. J Heart Transplant 7:356PubMedGoogle Scholar
  4. 4.
    Carrier M, Emery RW, Riley JE, et al. (1986) Cardiac transplantation in patients over the age of 50 years. J Am Coll Cardiol 8:285PubMedCrossRefGoogle Scholar
  5. 5.
    Copeland JG, Emery RW, Levinson MW, et al. (1987) Selection of patients for cardiac transplantation. Circulation 75:2PubMedCrossRefGoogle Scholar
  6. 6.
    Miller LW, Vitale-Noedel N, Pennington G, et al. (1988) Heart transplantation in patients over 55 years. J Heart Transplant 7:254PubMedGoogle Scholar
  7. 7.
    DiSesa VJ, Sloss LJ, Cohn LH (1990) Heart transplantation for intractable prosthetic valve endocarditis. J Heart Transplant 9:142PubMedGoogle Scholar
  8. 8.
    Miller LW, et al. (1989) Working group of transplant cardiologists. Cardiac Transplant (in press)Google Scholar
  9. 9.
    DiSesa VJ, Kou PC, Horvath KA, Mudge GH, Collins JJ, Cohn LH (1990) HLA histocompatibility affects cardiac transplant rejection and may provide one basis for organ allocation. Ann Thorac Surg 49:220–224PubMedCrossRefGoogle Scholar
  10. 10.
    DiSesa VJ, Kirkman RL, Tilney NL, et al. (1989) Management of general surgical complications following cardiac transplantation. Arch Surg 124:539PubMedCrossRefGoogle Scholar
  11. 11.
    Gao S-Z, Alderman EL, Schroeder JS, Silverman JF, Hunt SA (1988) Accelerated coronary vascular disease in the heart transplant patient: coronary arteriographic findings. J Am Coll Cardiol 12(2):334–340PubMedCrossRefGoogle Scholar
  12. 12.
    Katz MR, Barnhart GR, Szentpetery S, et al. (1988) Cardiac transplantation without maintenance steroids. Transplant Proc 20:751–752Google Scholar
  13. 13.
    Renlund DG, O’Connell JB, Gilbert EM, et al. (1987) Feasibility of discontinuation of corticosteroid maintenance therapy in heart transplantation. J Heart Transplant 6:71–78PubMedGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • Lawrence H. Cohn
    • 1
  • Gilbert H. Mudge
    • 2
  1. 1.Harvard Medical School and Division of Cardiac SurgeryBrigham and Women’s HospitalBostonUSA
  2. 2.Harvard Medical School and Division of CardiologyBrigham and Women’s HospitalBostonUSA

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