Abstract
Effects of prenatal supplementations of trace elements on fetal and neonatal developments in the mouse model of Menkes’ disease are investigated, The maternal administration of zinc, vitamin E and copper resulted in good effects on fetal and neonatal deaths and cerebral copper levels of offspring, especially those of hemizygous males, The development of Menkes’ offspring is influenced by the interaction of abnormal copper homeostasis and oxygen radical disturbances.
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References
Hunt D M (1974) Primary defect in copper transport underlies mottled mutants in the mouse. Nature 249: 852–854
Kasama T, Tanaka H (1988) Effects of copper administration on fetal and neonatal mice. J Nutr Sci Vitaminol 34: 595–605
Menkes J H, Alter M, Steigleder G K, Weakley D R, Sung J H (1962) A sex-linked recessive disorder with retardation of growth, peculiar hair, and focal cerebral and cerebellar degeneration. Pediatrics 29: 764–779
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© 1990 Springer-Verlag Tokyo
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Tanaka, H., Kasama, T., Arima, M. (1990). Prevention Possibility for Brain Dysfunction in Menkes’ Disease by Maternal Administration of Trace Elements. In: Tomita, H. (eds) Trace Elements in Clinical Medicine. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68120-5_37
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DOI: https://doi.org/10.1007/978-4-431-68120-5_37
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68122-9
Online ISBN: 978-4-431-68120-5
eBook Packages: Springer Book Archive