Abstract
Aluminum toxicity is a serious disorder of medical progress which occurs mostly in patients with renal failure. Aluminum enters the body either internal or parenterally. Principle toxicities are bone, brain and blood (anemia). Prevention is important - - - by limiting or avoiding aluminum. Treatment with the chelator, deferozamine is effective but hazardous.
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References
Alfrey AC (1986) Aluminum metabolism. Kidney Int 295: 8–11
Alfrey AC (1986b) Dialysis encephalopathy. Kidney Int 295: 53–57
Andreoli BP, Bergstein JM, Sherrard DJ (1984) Aluminum intoxication from alumina-containing phosphate binders in children with azotemia not undergoing dialysis. N Engl J Med 310: 1079–1084.
Andress DL, Kopp JB, Maloney HA, Coburn JW, Sherrard DJ (1987) The early deposition of aluminum in bone in diabetic patients on hemodialysis. N Engl J Med 316: 292–296
Coburn JW, Morris KC, Sherrard DJ, Bia M, Llach F, Alfrey AC, Slatopolsky E (1988) Toxic effects of aluminum in end stage renal disease. Am J Kidney Dis 12: 171–184
Goodnan WG (1988) The spectrum of alimlniMi intoxication in man and potential mechanisms of tissue injury. Proceedings 8th International Conference on Calcium Regulating Hormones (in press).
Kachny WD, Hegg P, Alfrey AC (1977) Gastrointestinal absorption of aluminum from alianinum- containing antacids. V E%1 J Med 296: 1389–1390.
Millner DS, Shinabexger JH, Shuman P, Coburn JW (1985) Inadvertent alianlr»» administration during plasma esxcharee due to aluminum contamination of albrain-replacement solutions. N Engl J Med 312: 165–167.
Ott SM, Maloney HA, Klein GL, Alfrey AC, Ament ME, Coburn JW, Sherrard DJ (1983) Aluminum is associated with low bone formation in patients receiving chronic parenteral nutrition. Am Intern Med 98: 910–914
Becker HR, Blotcky AJ, Leffler JA, Rack EP (1977) Evidence for alimrinian absorption from the gastrointestinal tract and bone deposition by aluninum carbonate ingestion with normal renal function. J Lab Clin Med 90: 810–817
Sherrard DJ, Ott SM, Andress DL (1986) Pbendkshyperpamthyroidism. Am J Med 79: 127–130.
Sherrard DJ, Walker JV, Boykin JL (1988) Precipitation of dialysis dementia by deferoxamine treatment of aluminum-related bone disease. Am J Kidney Dis 12: 126–130
Slanina P, French W, Ekstrom L, Loof L, Slorach S, Cedergren A (1986) Dietary citric acid enhances absorption of aluninum in antacids, clin Chen 32: 539–541
Swartz RD (1985) Deferoxamine and aluminum removal. Am J Kidney Dis 6: 358–364
Swartz R, Donbrouski J, Burnatowska, HLedin M, Mayor 6 (1987) Microcytic anemia in dialysis patients; Reversible marker of aliilnum toxicity. Am J Kidney Dis 9: 217–223
Williams JW, Vera SR, Peters TS, Luther BW, Ehattacharya S, Spears H, Graham A, Pitcock JA, Crawford AJ (1986) Biliary excretion of aluminum in aluminum osteodystrophy with renal disease. Am Intern Med 104: 782–785
Hindus DW, Stokes TJ, Julian BA, Fenves AZ (1987) Fatal rhiaqpus infections in hemodialysis patients receiving deferoxamine. Am Intern Med 107: 678–680
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© 1990 Springer-Verlag Tokyo
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Sherrard, D.J. (1990). Aluminum Intoxication. In: Tomita, H. (eds) Trace Elements in Clinical Medicine. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68120-5_16
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DOI: https://doi.org/10.1007/978-4-431-68120-5_16
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68122-9
Online ISBN: 978-4-431-68120-5
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