Abstract
Zinc is an essential trace element whose metabolism is frequently disturbed in gastrointestinal diseases. Zinc deficiency may manifest in different ways, e. g. crusting skin lesions, anorexia, hypogonadism, or altered immune function. Mechanisms for this altered zinc metabolism include stress- related redistribution, poor dietary intake, impaired absorption and increased excretion through the urinary and GI tract. Thus, it is important that health care providers be aware that altered zinc metabolism is a frequent and correctable problem in many gastrointestinal diseases. Furthermore, this zinc deficiency may manifest itself in multiple different ways and challenge the diagnostic acumen of the health care provider.
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References
Bunker VW, Hinks LJ, Lawson MS, Clayton BE (1984) Assessment of zinc and copper status of healthy elderly people using metabolic balance studies and measurement of leukocyte concentrations. Am J Clin Nutr 40: 1096–1102
Fell GS, Cuthbertson DP, Morrison C, Fleck A, Queen K, Bessent RG, Husain SL (1973) Urinary zinc levels as an indication of muscle catabolism. Lancet 1: 280–282
Field HP, Whitley AJ, Srinivasan TR, Walker BE, Kelleher J (1987) Plasma and leukocyte zinc concentrations and their response to zinc supplementation in an elderly population. Internat J Vit Nutr Res 57: 311–317
Giroux E, Schechter PJ, Schoun J, Sjoerdsma A (1977) Reduced binding of added zinc in serum of patients with decompensated hepatic cirrhosis. Eur J Clin Invest 7: 71–73
Humphries L, Vivian B, Stuart M, McClain CJ (In press) Zinc deficiency and eating disorders. J Clin Psych
McClain CJ, Adams L, Shedlofsky S (1988) Zinc and the gastrointestinal system. Essential and Toxic Trace Elements in Human Health and Disease, pp 55–73
McClain CJ, Antonow DR, Cohen DA, Shedlofsky SI (1986a) Zinc metabolism in alcoholic liver disease. Alcoholism: Clin Exp Res 10: 582–589
McClain CJ, Cohen DA (1989) Increased tumor necrosis factor production by monocytes in alcoholic hepatitis. Hepatology 9: 349–351
McClain CJ, Kasarskis EJ, Allen JJ (1985) Functional consequences of zinc deficiency. Prog in Food Nutr Sci 9: 185–226
McClain CJ, Souter C, Zieve L (1980) Zinc deficiency: A complication of Crohn’s disease. Gastroenterology 78: 272–279
McClain CJ, Twyman DL, Ott LG, Rapp RP, Tibbs PA, Norton JA, Kasarskis EJ, Dempsey RJ, Young B (1986b) Serum and urine zinc response in head-injured patients. J Neurosurg 64: 224–230
Newsome DA, Swartz M, Leone NC, Elston RC, Miller E (1988) Oral zinc in macular degeneration. Arch Ophthalmol 106: 192–197
Turnlund JR, Durkin N, Costa F, Margen S (1986) Soluble isotope studies of zinc absorption and retention in young and elderly men. J Nutr 116: 1239–1247
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© 1990 Springer-Verlag Tokyo
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McClain, C.J., Marsano, L. (1990). Zinc and Gastrointestinal Diseases. In: Tomita, H. (eds) Trace Elements in Clinical Medicine. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68120-5_11
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DOI: https://doi.org/10.1007/978-4-431-68120-5_11
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68122-9
Online ISBN: 978-4-431-68120-5
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