A Pathohistological Study with Four Kinds of Stress Stimulations on Active Endolymphatic Hydrops in Guinea Pigs
Ménière’s disease is believed to show pathological features of endolymphatic hydrops [1, 2], but the etiology of this disease has not yet been ascertained. Many investigators , have attempted to create animal models with endolymphatic hydrops by obliterating the endolymphatic sac and duct. However, this method has been unable to adequately explain the development of Ménière’s disease because it uses simulated apparatus. On the other hand, Ménière’s disease is thought to develop as a result of stress to the inner ear mechanism although there have been no reports on endolymphatic hydrops induced by stress. We conducted a short-term experiment, creating active endolymphatic hydrops by stress load, to study the occurrence rate of endolymphatic hydrops. This was followed by a light-microscopic study on the changes in permeability of the cochlear lateral wall with horseradish peroxidase and a study of the dynamics of endolymphatic hydrops.
KeywordsOccurrence Rate Light Micrograph Stria Vascularis Stress Load Stellate Ganglion
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