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A Pathohistological Study with Four Kinds of Stress Stimulations on Active Endolymphatic Hydrops in Guinea Pigs

  • Katsuya Akioka
  • Yoshiyuki Kitaoku
  • Osamu Tanaka
  • Takashi Matsunaga

Abstract

Ménière’s disease is believed to show pathological features of endolymphatic hydrops [1, 2], but the etiology of this disease has not yet been ascertained. Many investigators [3], have attempted to create animal models with endolymphatic hydrops by obliterating the endolymphatic sac and duct. However, this method has been unable to adequately explain the development of Ménière’s disease because it uses simulated apparatus. On the other hand, Ménière’s disease is thought to develop as a result of stress to the inner ear mechanism although there have been no reports on endolymphatic hydrops induced by stress. We conducted a short-term experiment, creating active endolymphatic hydrops by stress load, to study the occurrence rate of endolymphatic hydrops. This was followed by a light-microscopic study on the changes in permeability of the cochlear lateral wall with horseradish peroxidase and a study of the dynamics of endolymphatic hydrops.

Keywords

Occurrence Rate Light Micrograph Stria Vascularis Stress Load Stellate Ganglion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Yamakawa K (1938) Über die pathologische Veränderung bei einem Ménière-Kranken. J Otolaryngol Jpn 44: 2310–2312Google Scholar
  2. 2.
    Hallpike CS, Cairns H (1938) Observations on the pathology of Ménière’s syndrome. J Laryngol Otol 53: 625–655CrossRefGoogle Scholar
  3. 3.
    Kimura RS (1976) Experimental pathogenesis of hydrops. Arch Otorhinolaryngol 212: 263–275PubMedCrossRefGoogle Scholar
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    Naito T (1973) Ménière’s disease (in Japanese). Pract Otol (Kyoto) 66: 1–50Google Scholar
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    Sakagami M, Matsunaga T, Hashimoto PH (1982) Ultrastructural study on the permeability of blood vessels in the inner ear: Capillaries of the stria vascularis and spiral ligament (in Japanese). Practica Otol (Kyoto) 75: 2451–2458Google Scholar

Copyright information

© Springer-Verlag Tokyo 1990

Authors and Affiliations

  • Katsuya Akioka
  • Yoshiyuki Kitaoku
  • Osamu Tanaka
  • Takashi Matsunaga

There are no affiliations available

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