An Animal Model: Ménière’s Disease Attack

  • Kaoru Uchida
  • Masaaki Kitahara


Endolymphatic hydrops (EH) generally appears to be caused by an imbalance between the secretion and absorption of endolymphatic fluid. Although a model of Ménière’s disease has been experimentally produced by inhibiting the absorption of endolymphatic fluid in the endolymphatic sac, it is inappropriate as a model of Ménière’s disease since it does not display vertiginous attacks [1–3]. Ménière’s attack models have been produced in the past through the use of immunologic reactions [4, 5]. However, such models are considered to be histopathologically different from Ménière’s disease, since the existence of considerable precipitation in the perilymphatic spaces indicates the presence of serous labyrinthitis. Kitahara et al. [6] developed a successful Ménière’s attack model based on excessive endolymph production by injecting artificial endolymph into the perilymphatic space and the scala media. This fact suggests that excessive endolymph secretion plays a greater role in the occurrence of Ménière’s attack than insufficient endolymph absorption.


Stria Vascularis Spontaneous Nystagmus Endolymphatic Hydrops Endolymphatic Hydrops Cochlear Turn 
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© Springer-Verlag Tokyo 1990

Authors and Affiliations

  • Kaoru Uchida
  • Masaaki Kitahara

There are no affiliations available

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