The Developmental Pattern of Experimental Hydrops in the Endolymphatic Space

  • Yoshiro Yazawa


Endolymphatic hydrops in the temporal bones of Ménière’s disease patients was first described in 1938 by Yamakawa [1] and Hallpike and Cairns [2]. The first successful experimental induction of this condition was by Naito [3] and Kimura and Schuknecht [4], who, in separate studies, produced endolymphatic hydrops in guinea pigs through the obliteration of the endolymphatic duct or sac.


Temporal Bone Basal Turn Endolymphatic Hydrops Cochlear Duct Cochlear Aqueduct 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Yamakawa K (1938) Über die pathologische Veränderung bei einem Meniere-Kranken. J Otolaryngol Jpn 44: 2310–2312Google Scholar
  2. 2.
    Hallpike CS, Cairns H (1938) Observations on the pathology of Ménière’s syndrome. J Laryngol 53: 625–655Google Scholar
  3. 3.
    Naito T (1959) Clinical and pathological studies on Ménière’s disease. In: Proceedings of the 60th annual meeting of the oto-rhino-laryngological society of Japan (in Japanese) 1959, Tokyo, p 46Google Scholar
  4. 4.
    Kimura RS, Schuknecht HF (1965) Membranous hydrops in the inner ear of the guinea pig after obliteration of the endolymphatic sac. Pract Oto-rhino-laryng 27: 343–354Google Scholar
  5. 5.
    Yanagi Y (1973) Patterns of hair cell damage of the cochlea due to intense sound stimulation and the cochlear potentials in the guinea pig with experimentally induced endolymphatic hydrops (in Japanese). J Otolaryngol Jpn 76: 61–75Google Scholar
  6. 6.
    Suh KW, Cody DT (1974) Obliteration of vestibular and cochlear aqueducts in the guinea pig. Laryngoscope 84: 1352–1368PubMedCrossRefGoogle Scholar
  7. 7.
    Ruding PRJW, Veldman JE, van Deelen GW, Smoorenburg GE, Huizing EH (1987) Histopathological study of experimentally induced endolymphatic hydrops with emphasis on Reissner’s membrane. Arch Otorhinolaryngol 244: 174–179PubMedCrossRefGoogle Scholar
  8. 8.
    Yazawa Y (1981) Histopathological study of endolymphatic hydrops (in Japanese). Pract Otol (Kyoto) 74: 2450–2506Google Scholar
  9. 9.
    Yazawa Y, Shea J J, Kitahara M (1985) Endolymphatic hydrops in guinea pigs after cauterizing the sac with silver nitrate. Arch Otolaryngol 111: 301–304PubMedGoogle Scholar
  10. 10.
    Yazawa Y, Kitahara M (1989) Elasticity of Reissner’s membrane in endolymphatic hydrops (in Japanese). Equilibrium Res [Suppl] 5: 96–100CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1990

Authors and Affiliations

  • Yoshiro Yazawa

There are no affiliations available

Personalised recommendations