The Treatment of Ménière’s Disease with Isosorbide
It is widely accepted that endolymphatic hydrops is a common pathological feature of Ménière’s disease. Therefore, at present, the most logical and effective medical treatment for this ailment is believed to be with drugs which reduce hydrops. Isosorbide (ISO) has been shown to be effective for glaucoma and intracranial hypertension, the pathologies of which are similar to that of Ménière’s disease. In this paper, in order to determine the efficacy of ISO with regard to Ménière’s disease, we attempted, in cooperation with 14 other institutes, a double-blind crossover trial of ISO on Meniere’s disease.
KeywordsHearing Loss Utility Rating Global Improvement Rebound Phenomenon Endolymphatic Hydrops
Unable to display preview. Download preview PDF.
- 4.Goodhill V, Harris I (1979) Peripheral vertigo and Ménière’s disease. In: Goodhill V (ed) Ear diseases, deafness and dizziness. Harper and Row, New York, pp 526–544Google Scholar
- 7.Muskat J (1956) Urea in Ménière’s disease and allied conditions; preliminary report. Arch Otorhinolaryngol 64: 241–242Google Scholar
- 9.Larsen H, Stahle J (1984) The effect of isosorbide and urea on hearing in patients with Ménière’s disease. Acta Otolaryngol (Stockh) 412: 113–114Google Scholar
- 11.Kitano H, Kitahara M (1983) Treatment of Ménière’s disease with isosorbide and steroid (in Japanese). Pract Otol (Kyoto) 76: 702–707Google Scholar
- 12.Yazawa Y (1981) Histopathological study of endolymphatic hydrops (in Japanese). Pract Otol (Kyoto) 74: 2450–2506Google Scholar
- 13.Stahle J (1984) Medical treatment of fluctuant hearing loss. Acta Otolaryngol (Stockh) 53: 258–263Google Scholar