Characteristics of Vascular Smooth Muscle Cell Membranes and Their Modifying Factors

  • K. Kitamura
  • T. Itoh
  • Y. Ito
  • H. Kuriyama


In vascular smooth muscle, there are K channels (Ca-sensitive and insensitive, ATP-sensitive and less sensitive), Na channels (tetrodotoxin-sensitive and less sensitive), voltage-sensitive Ca channels, and receptor-activated (operated) cation-channels. These channel activities are important in the maintenance of electrical events in the smooth muscle cell membrane and in Ca regulation. These ionic channels are regulated directly or indirectly via synthesis of second messengers by various factors such as adrenergic innervation, humoral substances, endothelium-derived contracting and relaxing factors (endothelium-derived relaxing and hyperpolarizing factors, prostaglandin I2, endothelin, and thromboxane A2-like substance). In this article, the biophysical features of vascular smooth muscle cell membranes are reviewed in relation to coronary vasospasm, as well as the actions of some clinical drugs—nitro-(nitroso-, nitrite-) compounds, β-adrenoceptor blockers, Ca antagonists, and K channel openers—on ionic channels in vascular smooth muscle cells.


Smooth Muscle Cell Porcine Coronary Artery Endothelium Derive Hyperpolarizing Factor Single Smooth Muscle Cell Smooth Muscle Cell Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Ebashi S, Koga R (1988) Desensitization of smooth muscle natural actomyosin. Proc Japan Acad 64B: 98–101CrossRefGoogle Scholar
  2. 2.
    Ebashi S, Mikawa T, Kuwayama H, Suzuki H, Ikemoto H, Ishizaki Y, Koga R (1987) In: Sigman M, Somlyo AP, Stierens NN (eds) Ca2+ regulation of smooth muscle: Dissociation of myosin light chain kinase activity from activations of actin-myosin-interaction. Alan R Liss, New York pp 109–117Google Scholar
  3. 3.
    Ebashi S, Nonomiya Y, Nakamura S, Nakasone H, Kohama K (1982) Regulatory mechanism in smooth muscle: Actin-linked regulation. Fed Proc 41: 2863–2867PubMedGoogle Scholar
  4. 4.
    Mikawa T, Y. Nonomura, Ebashi S (1977) Does phosphorylation of myosin light chain have direct relation to regulation in smooth muscle? J Biochem 82: 1789–1791PubMedGoogle Scholar
  5. 5.
    Mikawa T, Nonomura Y, Hirata M, Ebashi S, Kakiuchi S (1978) Involvement of an acidic protein in regulation of smooth muscle contraction by the tropomyosin-leitotonin system. J Biochem 84: 1633–1636PubMedGoogle Scholar
  6. 6.
    Adelstein RS, Eisenberg E (1980) Regulation and kinetics of the actin-myosin-ATP interaction. Annu Rev Biochem 49: 921–956PubMedCrossRefGoogle Scholar
  7. 7.
    Hartshorne DJ, Gorecka J (1980) Biochemistry of the contractile proteins of smooth muscle. In Bethesda MD (ed) Handbook of physiology the cardiovascular system Am Physiol Soc sect 2, vol II, pp 93–120Google Scholar
  8. 8.
    Ikebe M, Inagaki M, Naka M, Hidaka H (1988) Correlation of conformation and phosphorylation and dephosphorylation of smooth muscle myosin. J Biol Chem 263: 10698–10704PubMedGoogle Scholar
  9. 9.
    Saida K, Nonomura Y (1978) Characteristics of Ca2+ and Mg2+-induced tension development in chemically skinned smooth muscle fibers. J Gen Physiol 72: 1–14PubMedCrossRefGoogle Scholar
  10. 10.
    Somlyo AV, Somlyo AP (1968) Electro mechanical and pharmacomechanical coupling in vascular smooth muscle. J Pharmacol Exp Ther 159: 129–159PubMedGoogle Scholar
  11. 11.
    Walsh MP (1985) Calcium regulation of smooth muscle contraction. In: Marine D (ed) Calcium and cell physiology. Springer Berlin Heidelberg New York TokyoGoogle Scholar
  12. 12.
    Onishi H, Wakabayashi T (1982) Electron microscopic studies of myosin molecules from chicken gizzard muscle I: The formation of the intramolecular loop in the myosin tail. J Biochem 92: 871–879PubMedGoogle Scholar
  13. 13.
    Suzuki H, Onishi H, Takahashi K, Watanabe S (1978) Structure and function of chicken gizzard myosin. J Biochem 84: 1529–1542PubMedGoogle Scholar
  14. 14.
    Corinna B, Rüegg JC, Takai A (1988) Effects of okadaic acid on isometric tension and myosin phosphorylation of chemically skinned guinea pig taenia coli. J Physiol 398: 81–95Google Scholar
  15. 15.
    Gabella G (1981) Structure of smooth muscles. In : Bülbring E, Brading AF, Jones AW, Tomita T (eds) Smooth muscle: An assessment of current knowledge. Edward Arnold, London, pp 1–46Google Scholar
  16. 16.
    Burnstock G (1972) Purinergic nerves. Pharmacol Rev 24: 509–581PubMedGoogle Scholar
  17. 17.
    Burnstock G (1980) Cholinergic and purinergic regulation of blood vessels. In: Bethesda MD (ed) Handbook of physiology. The cardiovascular system. Am Physiol Soc sect 2, vol II, pp 567–612Google Scholar
  18. 18.
    Burnstock G (1981) Neurotransmitters and trophic factors in the autonomic nervous system. J Physiol 313: 1–35PubMedGoogle Scholar
  19. 18.
    Bevan JA, Brayden JE (1987) Nonadrenergic neural vasodilator mechanisms. Circ Res 60: 309–326PubMedGoogle Scholar
  20. 19.
    Burnstock G (1981) Purinergic receptor. Chapman and Hall, LondonCrossRefGoogle Scholar
  21. 19.
    Bevan JA, Oriwo MA, Bevan RD (1986) Physiological variation in a-adrenoceptor mediated arterial sensitivity: Relation to agonist affinity. Science 234: 196–197PubMedCrossRefGoogle Scholar
  22. 20.
    Burnstock G (1981) Development of smooth muscle and its innervation. In: Bülbring E, Brading AF, Jones AW, Tomita T (eds) Smooth muscle: An assessment of current knowledge. Edward Arnold, London, pp 431–458Google Scholar
  23. 21.
    Bolton TB, Large WA (1986) Are junction potentials essential? Dual mechanism of smooth muscle cell activation by transmitter released from autonomic nerves. Q J Exp Physiol 71: 1–28PubMedGoogle Scholar
  24. 22.
    Burnstock G, Costa M (1975) Adrenergic Neurones. Chapman, and Hall, LondonGoogle Scholar
  25. 23.
    Bülbring E (1955) Correlation between membrane potential, spike discharge and tension in smooth muscle. J Physiol 125: 302–315Google Scholar
  26. 24.
    Hamill OP, Marty A, Neher E, Sakmann B, Sigworth F (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch 391: 85–100PubMedCrossRefGoogle Scholar
  27. 25.
    Neher E, Sakmann B (1976) Single-channel currents recorded from membrane of denervated frog muscle fibres. Nature 260: 799–802PubMedCrossRefGoogle Scholar
  28. 26.
    Ito Y, Kuriyama H (1971) Membrane properties of the smooth-muscle fibres of the guinea pig portal vein. J Physiol 214: 427–441PubMedGoogle Scholar
  29. 27.
    Ito Y, Kitamura K, Kuriyama H (1979) Effects of acetylcholine and catecholamines on the smooth muscle cell of the porcine coronary artery J Physiol 294: 595–611PubMedGoogle Scholar
  30. 28.
    Itoh T, Furukawa K, Kajiwara M, Kitamura K, Suzuki H, Ito Y, Kuriyama H (1981) Effects of 2-nicotinamidoethylnitrate on smooth muscle cells and on adrenergic transmission in the guinea pig and porcine mesenteric arteries. J Pharmacol Exp Ther 218: 260–270PubMedGoogle Scholar
  31. 29.
    Kajiwara M (1982) General features of electrical and mechanical properties of smooth muscle cells in the guinea pig abdominal aorta. Pflügers Arch 393: 109–117PubMedCrossRefGoogle Scholar
  32. 30.
    Kajiwara M, Kitamura K, Kuriyama H (1981) Neuromuscular transmission and smooth muscle membrane properties in the guinea pig ear artery. J Physiol 315: 283–302PubMedGoogle Scholar
  33. 31.
    Komori K, Chen G, Suzuki H (1989) Mechanisms of inhibitory noradrenergic transmission in the rabbit facial vein. Pflügers Arch 413: 359–364PubMedCrossRefGoogle Scholar
  34. 32.
    Komori K, Lorenz RR, Vanhoutte PM (1988) Nitric oxide, ACh and electrical and mechanical properties of canine arterial smooth muscle. Am J Physiol 255: H207–H212PubMedGoogle Scholar
  35. 33.
    Komori K, Suzuki H (1987) Heterogeneous distribution of muscarinic receptors in the rabbit saphenous artery. Br J Pharmacol 92: 657–664PubMedGoogle Scholar
  36. 34.
    Casteels R (1981) Membrane potential in smooth muscle cells. In: Bulbring E, Brading AF, Jones AW, Tomita T (eds) Smooth muscle: An assessment of current knowledge. Edward Arnold, London, pp 105–126Google Scholar
  37. 35.
    Creed KE (1979) Functional diversity of smooth muscle. Br Med Bull 35: 243–247PubMedGoogle Scholar
  38. 35.
    Caffrey JM, Josephson IR, Brown AM (1986) Calcium channels of amphibian and mammalian aorta smooth muscle cells. Biophys J 49 1237–1242PubMedCrossRefGoogle Scholar
  39. 36.
    Kuriyama H, Ito Y, Suzuki H, Kitamura K, Itoh T (1982) Factors modifying contraction-relaxation cycle in vascular smooth muscles. Am J Physiol 243: H641–H662PubMedGoogle Scholar
  40. 37.
    Benham CD, Bolton TB (1986) Spontaneous transient outward current in single visceral and vascular smooth muscle cells of the rabbit. J Physiol 381: 385–406PubMedGoogle Scholar
  41. 38.
    Benham CD, Bolton TB, Lang RJ, Takewaki T (1985) The mechanism of action of Ba2+ and TEA on single Ca2+-activated K+ channels in arterial and intestinal smooth muscle cell membrane. Pflügers Arch 403: 120–127PubMedCrossRefGoogle Scholar
  42. 39.
    Benham CD, Bolton TB, Lang RJ, Takewaki T (1986) Calcium activated potasium channels in single smooth muscle cells of rabbit jejunum and guinea pig mesenteric artery. J Physiol 371: 45–67PubMedGoogle Scholar
  43. 40.
    Berger W, Grygorcyk R, Schwarz W (1984) Single K+ channel in smooth muscles in membrane evaginations of smooth muscle cells. Pflügers Arch 402: 18–23.PubMedCrossRefGoogle Scholar
  44. 41.
    Inoue R, Kitamura K, Kuriyama H (1985) Two Ca-dependent K-channels classified by application of tetraethylammonium distribute to smooth muscle membranes of the rabbit portal vein. Pflügers Arch 405: 173–179PubMedCrossRefGoogle Scholar
  45. 42.
    Inoue R, Okabe K, Kitamura K, Kuriyama H (1986) A newly identified Ca2+ dependent K+ channel in the smooth muscle membrane of single cells dispersed from the rabbit portal vein. Pflügers Arch 406: 138–143PubMedCrossRefGoogle Scholar
  46. 43.
    Ohya Y, Kitamura K, Kuriyama H (1987) Modulation of ionic currents in smooth muscle balls of the intestine by intercellularly perfused ATP and cyclic AMP. Pflugers Arch 408: 465–473PubMedCrossRefGoogle Scholar
  47. 44.
    Ohya Y, Terada K, Kitamura K., Kuriyama H (1986) Membrane currents recorded from a fragment of rabbit intestinal smooth muscle cells. Am J Physiol 251: C335–C346PubMedGoogle Scholar
  48. 45.
    Okabe K, Kitamura K, Kuriyama H (1987) Features of 4-aminopyridine sensitive outward current observed in single smooth muscle cells from the rabbit pulmonary artery. Pflugers Arch 409: 561–568PubMedCrossRefGoogle Scholar
  49. 46.
    Sadoshima S, Akaike N, Tomoike H, Kanaide H, Nakamura M (1988) Ca-activated K channel in cultured smooth muscle cells of rat aortic media. Am J Physiol 225: H410–H418Google Scholar
  50. 47.
    Brayden JE, Large WA (1986) Electrophysiological analysis of neurogenic vasodilation in isolated lingual artery of the rabbit Br J Pharmacol 89: 163–171PubMedGoogle Scholar
  51. 48.
    Johnsson B, Somlyo AP (1980) Electrophysiology and excitation contraction coupling. In: Bohr F, Somlyo AP, Sparks HD Jr (eds) Handbook of Physiology sect 2, vol II: The cardiovascular system Am Physiol Soc, Bethesda, pp 301–324Google Scholar
  52. 49.
    Standen NB, Quayle JM, Davis NW, Brayden JE, Huang Y, Nelson MT (1989) Hyperpolarizing vasodilators activate ATP-sensitive K+-channels in arterial smooth muscle. Science 245: 177–180PubMedCrossRefGoogle Scholar
  53. 50.
    Kajioka S, Oike M, Kitamura K (1990) Nicorandil opens a Calcium-dependent potassium channel in smooth muscle cells of the rat portal vein. J Pharmacol Exp Ther 254: 905–913PubMedGoogle Scholar
  54. 51.
    Bolton TB, Lim SP (1989) Properties of calcium stores and transient outward currents in single smooth muscle cells of rabbit intestine. J Physiol 409: 385–401PubMedGoogle Scholar
  55. 52.
    Hume JR, Lebranc N (1989) Macroscopic K currents in single smooth muscle cells of the rabbit portal vein. J Physiol 413: 49–73PubMedGoogle Scholar
  56. 53.
    Ohya Y, Terada K, Yamaguchi K, Inoue R, Okabe K, Kitamura K, Hirata M, Kuriyama H (1988) Effects of inositol phosphates on the membrane activity of smooth muscle cells of the rabbit portal vein. Pflugers Arch 412: 382–389PubMedCrossRefGoogle Scholar
  57. 54.
    Sakai T, Terada K, Kitamura K, Kuriyama H (1988) Ryanodine inhibits the Ca-dependent KL current after depletion of Ca stored in smooth muscle cells of the rabbit ileal longitudinal muscle. Br J Pharmacol 95: 1089–1100PubMedGoogle Scholar
  58. 55.
    Ohya Y, Terada K, Kitamura K, Kuriyama H (1987) D600 blocks the Ca2+ channel from the outer surface of smooth muscle cell membrane of the rabbit intestinal and portal vein. Pflügers Arch 408: 80–82PubMedCrossRefGoogle Scholar
  59. 56.
    Akaike N, Kanaide H, Kuga T, Nakamura M, Sadoshima J, Tomoike H (1989) Low-voltage-activated calcium current in rat aorta smooth muscle cells in primary culture. J Physiol 416: 141–160PubMedGoogle Scholar
  60. 57.
    Bean BP, Sturek M, Puga A, Hermsmeyer K (1986) Calcium channels in muscle cells isolated from rat mesenteric arteries: Modulation by dihydropyridine drugs. Circ Res 59: 229–235PubMedGoogle Scholar
  61. 58.
    Friedman ME, Suarez-Kurts G, Kaczorowski GJ, Katz GM, Reuben JP (1986) Two calcium currents in a smooth muscle cell line. Am J Physiol 250: H699–703PubMedGoogle Scholar
  62. 59.
    Loirand G, Pacaud P, Mironneau C, Mironneau J (1986) Evidence for two distinct calcium channels in rat vascular smooth muscle cells in short-term primary culture. Pflugers Arch 407: 566–568PubMedCrossRefGoogle Scholar
  63. 60.
    Nowycky MC, Fox AP, Tsien RW (1985) Three types of neuronal calcium channel with different calcium agonist sensitivity. Nature 316: 440–443PubMedCrossRefGoogle Scholar
  64. 61.
    Kawashima Y, Ochi R (1987) Two types of calcium channels in isolated vascular smooth muscles. Jpn J Physiol 49: 369Google Scholar
  65. 62.
    Worley III JF, Deitmer JW, Nelson MT (1986) Single nisoldipine-sensitive calcium channels in smooth muscle cells isolated from rabbit mesenteric artery. Proc Natl Acad Sci USA 83: 5746–5750PubMedCrossRefGoogle Scholar
  66. 63.
    Furukawa K, Itoh T, Kajiwara M, Kitamura K, Suzuki H, Ito Y, Kuriyama H (1981) Vasodilating actions of 2-nicotin amidoethyl nitrate on porcine and guinea-pig coronary artery. J Pharmacol Exp Ther 218: 248–259PubMedGoogle Scholar
  67. 63.
    Benham CD, Hess P, Tsien RW (1987) Two types of calcium channels in single smooth muscle cells from rabbit ear artery studied with whole-cell and single-channel recordings. Circ Res 61 (Suppl 1): 10–16.Google Scholar
  68. 64.
    Yatani A, Seidel CL, Allen J, Brown AM (1987) Whole-cell and single-channel calcium currents of isolated smooth muscle cells from saphenous vein. Circ Res 60: 523–533PubMedGoogle Scholar
  69. 65.
    Yoshino M, Someya T, Nishino A, Yabu H (1988) Whole-cell and unitary Ca channel currents in mammalian intestinal smooth muscle cells: Evidence for existence of two types of Ca channels. Pflugers Arch 411: 229–231PubMedCrossRefGoogle Scholar
  70. 66.
    Holman ME (1970) Junction potentials in smooth muscle. In: Bülbring E, Brading AF, Jones AW, Tomita T (eds) Smooth muscle. Edward Arnold, London, pp 244–288Google Scholar
  71. 67.
    Holman ME, Surprenant AM (1979) Some properties of the excitatory junction potentials recorded from saphenous artery of rabbits. J Physiol 287: 337–351PubMedGoogle Scholar
  72. 68.
    Holman ME, Surprenant AM (1980) An electrophysiological analysis of the effects of noradrenaline and a-receptor antagonists on neuromuscular transmission in mammalian muscular arteries. Br J Pharmacol 71: 651–661PubMedGoogle Scholar
  73. 69.
    Kuriyama H, Makita Y (1984) The presynaptic regulation of noradrenaline release differs in mesenteric arteries of the rabbit and guinea pig. J Physiol 351: 379–396PubMedGoogle Scholar
  74. 70.
    Kou K, Ibengwe JK, Suzuki H (1984) Effects of alpha-adrenoceptor antagonists on electrical and mechanical responses of the isolated dog mesenteric vein to perivascular nerve stimulation and exogenous noradrenaline. Naunyn Schmiedebergs Arch Pharmacol 326: 357–363CrossRefGoogle Scholar
  75. 71.
    Suzuki H (1983) An electrophysiological study of excitatory neuromuscular transmission in the guinea-pig main pulmonary artery. J Physiol 336: 47–59PubMedGoogle Scholar
  76. 72.
    Ganitkevich VYA, Shuba MF, Smironou SV (1986) Potential-dependent calcium inward current in a single isolated smooth muscle cell of the guinea-pig taenia caeci. J PHysiol 380: 1–16PubMedGoogle Scholar
  77. 73.
    Inoue Y, Oike M, Nakao K, Kitamura K, Kuriyama H (1990) Endothelin augments unitary calcium channel currents on the smooth muscle cell membrane of guinea-pig portal vein. J Physiol 423: 171–191PubMedGoogle Scholar
  78. 74.
    Bolton TB (1979) Mechanisms of action of transmitters and other substances on smooth muscle. Physiol Rev 59: 606–718PubMedGoogle Scholar
  79. 75.
    Benham CD, Tsien RW (1987) A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle. Nature 328: 275–278PubMedCrossRefGoogle Scholar
  80. 76.
    Droogmans G, Declerck I, Casteels R (1987) Effects of adrenergic agonists on Ca2+-channel currents in single vascular smooth muscle cells. Pflugers Arch 409: 7–12PubMedCrossRefGoogle Scholar
  81. 77.
    Nelson MT, Standen NB, Brayden JE, Worley III JF (1988) Noradrenaline contracts arteries by activating voltage-dependent calcium channel. Nature 336: 382–385PubMedCrossRefGoogle Scholar
  82. 78.
    Okabe K, Kitamura K, Kuriyama H (1988) The existence of a highly tetrodotoxin sensitive Na channel in freshly dispersed smooth muscle cells of the rabbit main pulmonary artery. Pflugers Arch 411: 423–428PubMedCrossRefGoogle Scholar
  83. 79.
    Amédée T, Renaud JF, Jmari J, Lombert A, Mironneau J (1986) The presence of Na+ channel in myometrial smooth muscle cells is revealed by specific neurotoxins. Biochem Biophys Res Commun 137: 675–681PubMedCrossRefGoogle Scholar
  84. 80.
    Sturek M, Hermsmeyer K (1986) Calcium and sodium channels in spontaneously contracting vascular muscle cells. Science 233: 475–478PubMedCrossRefGoogle Scholar
  85. 81.
    Bell C (1968) Dual vasoconstrictor and vasodilator innervation of the uterine arterial supply in the guinea pig. Circ Res 23: 279–289PubMedGoogle Scholar
  86. 82.
    Bell C (1969) Transmission from vasoconstrictor and vasodilator nerve to single smooth muscle cells of the guinea pig uterine artery. J physiol 205: 695–708PubMedGoogle Scholar
  87. 83.
    Nakazato Y, Ohya Y, Sigei T, Uematsu T (1982) Extrinsic innervation of the canine abdominal vena cava and the origin of cholinergic vasoconstrictor nerve. J Physiol 328: 191–203PubMedGoogle Scholar
  88. 84.
    Kuriyama H, Suzuki H (1981) Adrenergic transmissions in the guinea-pig mesenteric artery and their cholinergic modulations. J Physiol 317: 383–396PubMedGoogle Scholar
  89. 85.
    Cheung DW (1982) Two components in cellular response of rat tail arteries to nerve stimulation. J Physiol 328: 461–468PubMedGoogle Scholar
  90. 86.
    Hirst GDS, Edwards FR (1989) Sympathetic neuroeffector transmission in arteries and arterioles. Physiol Rev 69: 546–604PubMedGoogle Scholar
  91. 87.
    Hirst GDS, Neild TO (1980) Evidence for two populations of excitatory receptors for noradrenaline on arteriolar smooth muscle. Nature 283: 767–768PubMedCrossRefGoogle Scholar
  92. 88.
    Hirst GDS, Neild To (1981) Localization of specialized noradrenaline receptors at neuromuscular junctions on arterioles of the guinea pig. J Physiol 313: 343–350PubMedGoogle Scholar
  93. 89.
    Hirst GDS, Neild TO, Silverberg GD (1982) Noradrenaline receptors on the rat basilar artery. J Physiol 328: 351–360PubMedGoogle Scholar
  94. 90.
    Itoh T, Kuriyama H, Suzuki H (1981) Excitation-contraction coupling in smooth muscle cells of the guinea pig mesenteric artery. J Physiol 321: 515–535Google Scholar
  95. 91.
    Kuriyama H, Makita Y (1982) Modulation of neuromuscular transmission by endogenous and exogenous prostaglandins in the guinea pig mesenteric artery. J Physiol 327: 431–448PubMedGoogle Scholar
  96. 92.
    Langer SZ (1974) Presynaptic regulation of catecholamine release. Biochem Pharmacol 23: 1793–1800PubMedCrossRefGoogle Scholar
  97. 93.
    Suzuki H, Mishima S, Miyahara H (1984) Effects of reserpine treatment on electrical responses evoked by perivascular nerve stimulation in the rabbit ear artery. Biomed Res 5: 259–266Google Scholar
  98. 94.
    Burnstock G, Kennedy C (1986) A dual function for adenosine 5’-triphosphate in the regulation of vascular tone. Circ Res 58: 319–350PubMedGoogle Scholar
  99. 95.
    Burnstock G, Kennedy C (1986) Purinergic receptors in the cardiovascular system. Prog Pharmacol vol 6 (2): 111–132Google Scholar
  100. 96.
    Byrne NG, Large WA (1986) The effects of α,β-methylene ATP on the depolarization evoked by noradrenaline e-adrenoceptor response and ATP in the immature rat basilar artery. Br J Pharmacol 88: 6–8PubMedGoogle Scholar
  101. 97.
    Cheung DW, Fujioka M (1987) Inhibition of the junction potential in the guinea-pig saphenous artery by ANAPP3. Br J Pharmacol 89: 3–5Google Scholar
  102. 98.
    Ishikawa S (1985) Actions of ATP and a, ß, -methylene ATP in neuromuscular transmission and smooth muscle membrane of the rabbit and guinea pig mesenteric arteries. Br J Pharmacol 86: 777–787PubMedGoogle Scholar
  103. 99.
    Komori K, Suzuki H (1987) Electrical responses of smooth muscle cells during cholinergic vasodilation in the rabbit saphenous artery. Circ Res 61: 586–593PubMedGoogle Scholar
  104. 100.
    Miyahara H, Suzuki H (1987) Pre-and post-junctional effects of adenosine triphosphate on noradrenergic transmission in the rabbit ear artery. J Physiol 389: 423–440PubMedGoogle Scholar
  105. 101.
    Sneddon P, Burnstock G (1985) ATP as a co-transmitter in rat tail artery. Eur J Pharmacol 106: 149–152CrossRefGoogle Scholar
  106. 102.
    Suzuki H (1985) Electrical responses of smooth muscle cells of the rabbit ear artery to adenosine triphosphate. J Physiol 359: 401–415PubMedGoogle Scholar
  107. 103.
    Nakao K, Okabe K, Kitamura K, Kuriyama H (1988) Characteristics of cromakalim-induced relaxation in the smooth muscle cells of guinea-pig mesenteric artery and vein. Br J Pharmacol 95: 795–804PubMedGoogle Scholar
  108. 104.
    Suzuki H (1989) Electrical activities of vascular smooth muscles in response to acetylcholine. Asia Pacific J Pharmacol 4: 141–150Google Scholar
  109. 105.
    Langer SZ (1981) Presynaptic regulation of the release of catecholamines. Pharmacol Rev 32: 337–362Google Scholar
  110. 106.
    Langer SZ, Lehmann J (1988) Presynaptic receptors on catecholamine neurones. In: Tren deleuburg U, Weiner N (eds) Handbook of experimental pharmacology. Catecholamines I vol 85 (1) Springer Berlin pp 419–507Google Scholar
  111. 107.
    Starke K (1987) Presynaptic a-autoreceptors. Rev Physiol Biochem Pharmacol 107: 73–146PubMedCrossRefGoogle Scholar
  112. 108.
    Starke K, Göthert M, Kilbinger H (1989) Modulation of neurotransmitter release by presynaptic autoreceptors. Physiol Rev 69: 864–989PubMedGoogle Scholar
  113. 109.
    Starke K, Langer SZ (1979) A note on terminology for presynaptic receptors. In: Langer SZ, Starke K, Dubocorich ML (eds) Presynaptic receptors Pergamon, Oxford pp 1–3Google Scholar
  114. 110.
    Ishikawa T, Yanagisawa M, Kimura S, Goto K, Masaki T (1988) Positive inotropic action of novel vasoconstrictor peptide endothelin on guinea pig atria. Am J Physiol 255: H970–973PubMedGoogle Scholar
  115. 111.
    Majewski H (1983) Modulation of noradrenaline release through activation of presynaptic β-adrenoceptors. J Auton Pharmacol 13: 47–60CrossRefGoogle Scholar
  116. 112.
    Makita Y (1983) Effects of prostaglandin I2 and carbo cyclic thromboxane A2 on smooth muscle cells and neuromuscular transmission in the guinea-pig mesenteric artery. Br J Pharmacol 78: 517–527PubMedGoogle Scholar
  117. 113.
    Makita Y (1984) Effects of adrenoceptor agonists and antagonists on smooth muscle cells and neuromuscular transmission in the guinea-pig renal artery and vein. Br J Pharmacol 80: 671–679Google Scholar
  118. 114.
    Casteels R, Kitamura K, Kuriyama H, Suzuki H (1977) The membrane properties of the smooth muscle cells of the rabbit main pulmonary artery. J Physiol 271: 41–61PubMedGoogle Scholar
  119. 115.
    Casteels R, Kitamura K, Kuriyama H, Suzuki H (1977) Excitation-contraction coupling in the smooth muscle cells of the rabbit main pulmonary artery. J Physiol 271: 62–79Google Scholar
  120. 116.
    Droogmans G, Raeymaekers L, Casteels R (1977) Electro and pharmacomechanic-al coupling in the smooth muscle cells of the rabbit ear artery. J Gen Physiol 70: 129–148PubMedCrossRefGoogle Scholar
  121. 117.
    Itoh T, Ueno H, Kuriyama H (1985) Calcium-induced calcium release mechanism in vascular smooth muscles: Assessments based on contractions evoked in intact and saponin-treated skinned muscles. Experientia 41: 989–996PubMedCrossRefGoogle Scholar
  122. 118.
    Suematsu E, Hirata M, Hashimoto T, Kuriyama H (1984) Inositol 1,4,5-trisphosphate releases Ca2+ from intracellular store sites in skinned single cells of porcine coronary artery. Biochem Biophys Res Commun 120: 481–485PubMedCrossRefGoogle Scholar
  123. 119.
    Suematsu E, Hirata M, Sasaguri T, Hashimoto T, Kuriyama H (1985) Roles of Ca2+ on the inositol 1,4,5-trisphosphate-induced release of Ca2+ from saponin-permeabilized single cells of the porcine coronary artery. Comp Biochem Physiol 82A: 645–649Google Scholar
  124. 120.
    Hashimoto T, Hirata M, Itoh T, Kanmura Y, Kuriyama H (1986) Inositol 1,4, 5-trisphosphate activates pharmacomechanical coupling in smooth muscle of the rabbit mesenteric artery. J Physiol 370: 605–618PubMedGoogle Scholar
  125. 121.
    Somlyo AV, Bond M, Somlyo AP, Scarpa A (1985) Inositol trisphosphate-induced calcium release and contraction in vascular smooth muscle. Proc Natl Acad Sci USA 82: 5231–5235PubMedCrossRefGoogle Scholar
  126. 122.
    Su C, Bevan JA, Ursillo RC (1964) Electrical quiescence of pulmonary artery smooth muscle during sympathetic stimulation. Circ Res 15: 20–27Google Scholar
  127. 123.
    Ohya Y, Kitamura K, Kuriyama H (1987) Cellular calcium regulates outward currents in rabbit intestinal smooth muscle cell. Am J Physiol 252: C401–C410PubMedGoogle Scholar
  128. 124.
    Walker JW, Somlyo AV, Goldman YE, Somlyo AP, Trentham DR (1987) Kinetics of smooth and skeletal muscle activation by laser pulse photolysis of caged inositol 1, 4, 5-trisphosphate. Nature 327: 249–252PubMedCrossRefGoogle Scholar
  129. 125.
    Yamamoto H, van Breemen C (1985) Inositol-1,4,5-trisphosphate release calcium from skinned cultured smooth muscle cells. Biochem Biophys Res Commun 130 (1): 270–274PubMedCrossRefGoogle Scholar
  130. 126.
    Abdel-Latif AA (1986) Calcium-mobilizing receptors, polyphospho-inositides, and the generation of second messengers. Pharmacol Rev 38: 227–272PubMedGoogle Scholar
  131. 127.
    Berridge MJ (1984) Inositol trisphosphate and diacylglycerol as second messengers. Biochem J 220: 345–360PubMedGoogle Scholar
  132. 128.
    Berridge MJ (1987) Inositol trisphosphate and diacylglycerol: Two interacting sceond messengers. Annu Rev Biochem 56: 159–193PubMedCrossRefGoogle Scholar
  133. 129.
    Berridge MJ, Irvine RF (1984) Inositol trisphosphate, a novel sceond messenger in cellular signal transduction. Nature 312: 315–321PubMedCrossRefGoogle Scholar
  134. 130.
    Berridge MJ, Irvine RF (1989) Inositol phosphates and cell signalling. Nature 341: 197–205PubMedCrossRefGoogle Scholar
  135. 131.
    Nishizuka Y (1984) The role of protein kinase C in cell surface signal transduction and tumor promotion. Nature 308: 693–698.PubMedCrossRefGoogle Scholar
  136. 132.
    Nishizuka Y (1986) Studies and prospectives of protein kinase C. Scinece 233: 305–312CrossRefGoogle Scholar
  137. 133.
    Nishizuka Y (1988) The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature 344: 661–665CrossRefGoogle Scholar
  138. 134.
    Streb H, Irvine RF, Berridge MJ, Schulz I (1983) Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature 306: 64–69CrossRefGoogle Scholar
  139. 135.
    Furchgott RF, Zawadzki JV (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288: 373–376PubMedCrossRefGoogle Scholar
  140. 136.
    Furchgott RF (1984) The role of endothelium in the responses of vascular smooth muscle to drugs. Annu Rev Pharmacol Toxicol 24: 175–195PubMedCrossRefGoogle Scholar
  141. 137.
    De Mey JG, Gläye M, Vanhoutte PM (1982) Endothelium-dependent inhibitory effects of acetylcholine, adenosine triphosphosphate, thrombin and arachidonic acid in the canine femoral artery. J Pharmacol Exp Ther 222: 166–173PubMedGoogle Scholar
  142. 138.
    Van Breemen C, Aaronson P, Loutzenhiser R (1979) Sodium-calcium interactions in mammalian smooth muscle. Pharmacol Rev 30: 164–208Google Scholar
  143. 139.
    Ignarro LJ (1989) Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein. Circ Res 65: 1–21PubMedGoogle Scholar
  144. 140.
    Ignarro LJ, Ballot B, Wood KS (1984) Regulation of soluble guanylate cyclase activity by porphyrins and metalloporphyrins. J Biol Chem 259: 6201–6207PubMedGoogle Scholar
  145. 141.
    Ignarro LJ, Gruetter CA (1980) Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite: Possible involvement of S-nitrosothiols. Biochim Biophys Acta 631: 221–231PubMedCrossRefGoogle Scholar
  146. 142.
    Ignarro LJ, Harbison RG, Wood KS, Kadowitz PJ (1986) Activation of purified Soluble guanylate cyclase by endothelium-derived relaxing factor from intrapul-monary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid. J Pharmacol Exp Ther 237: 893–900PubMedGoogle Scholar
  147. 143.
    Ignarro LJ, Kadowitz PJ (1985) Pharmacological and physiological role of cyclic GMP in vascular smooth muscle relaxation. Ann Rev Pharmacol 25: 171–191CrossRefGoogle Scholar
  148. 144.
    Ignarro Lj, Lippton H, Edwards JC, Baricos WH, Hyman AL, Kadowitz PJ, Gruetter CA (1981) Mechanism of vascular smooth muscle relaxation by organic nitrates, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. J Pharmacol Exp Ther 218: 739–749.PubMedGoogle Scholar
  149. 145.
    Murad F (1986) Cyclic guanosine monophosphate as a mediator of vasodilation. J Clin Invest 78: 1–5PubMedCrossRefGoogle Scholar
  150. 146.
    Rapoport RM, Murad F (1983) Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circ Res 52: 352–357PubMedGoogle Scholar
  151. 147.
    Rapoport RM, Draznin MB, Murad F (1982) Sodium nitroprusside-induced protein phosphorylation in intact rat aorta is mimcked by 8-bromo cyclic GMP. Proc Natl Acad Sci USA 79: 6470–6474PubMedCrossRefGoogle Scholar
  152. 148.
    Palmer PM, Ashton DS, Moncada S (1988) Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 333: 664–666PubMedCrossRefGoogle Scholar
  153. 149.
    Palmer PM, Ferrige PG, Moncada S (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327: 524– 526PubMedCrossRefGoogle Scholar
  154. 150.
    Rees DD, Palmer RMJ, Hodson HF, Moncada S (1989) A specific inhibitor of nitric oxide formation from L-arginine attenuates endothelium-dependent relaxation. Br J Pharmacol 96: 418–424PubMedGoogle Scholar
  155. 151.
    Raeymaeker L, Hoffmann F, Casteels R (1988) Cyclic GMP-dependent protein kinase phosphorylates phospholambane in isolated sarcoplasmic reticulum from cardiac and smooth muscle. Biochem J 252: 269–273Google Scholar
  156. 152.
    Chen G, Suzuki H, Weston AH (1988) Acetylcholine releases endotheliumderived hyperpolarizing factor and EDRF from rat blood vessels. Br Pharmacol 95: 1165–1174Google Scholar
  157. 153.
    Nishiye E, Chen G, Kuriyama H (to be published) Regulation of vascular tone; endothelium derived regulating factors in the guinea pig coronary artery. Br J PharmacolGoogle Scholar
  158. 154.
    Nishiye E, Nakao K, Itoh T, Kuriyama H (1989) Factors inducing endothelium-dependent relaxation in the guinea pig basilar artery as estimated from the action of hemoglobin. Br J Pharmacol 96: 645–655PubMedGoogle Scholar
  159. 155.
    Moncada S, Ferreira SH, Bunting S, Vane JR (1977) An enzyme isolated from arteries transformed prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 263: 663–665CrossRefGoogle Scholar
  160. 156.
    Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T (1988) A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332: 411–415PubMedCrossRefGoogle Scholar
  161. 157.
    Shirahase H, Usui H, Kurahashi K, Fujiwara M, Fukui K (1987) Possible role of endothelial thromboxane A2 in the resting tone and contractile responses to acetylcholine and arachidonic acid in canine cerebral arteries. J Cardiovasc Pharmacol 10: 517–522PubMedCrossRefGoogle Scholar
  162. 158.
    Ishikawa S, Sperelakis N (1987) A novel class (H3) of histamine receptors on perivascular nerve terminals Nature 327: 158–160PubMedCrossRefGoogle Scholar
  163. 159.
    Lippton H, Goff J, Hymanm A (1988) Effects of endothelin in the systemic and renal vascular beds in vivo. Eur J Pharmacol 155: 197–199PubMedCrossRefGoogle Scholar
  164. 160.
    Warner T, De Nucci G, Vane JR (1988) Release of EDRF by endothelin in the rat isolated perfused mesentery. Br J Pharmacol 95: 723Google Scholar
  165. 161.
    Goto K, Kasuya Y, Matsuki N, Takuwa Y, Kurihara H, Ishikawa T, Kimura S, Yanagisawa M, Masaki T (1989) Endothelin activates the dihydropyridinesensitive, voltage-dependent Ca2+ channel in vascular smooth muscle. Proc Natl Acad Sci USA 86: 3915–3918PubMedCrossRefGoogle Scholar
  166. 162.
    Ishikawa T, Yanagisawa M, Kimura S, Goto K, Masaki T (1989) Positive chronotropic effects of endothelin: A novel endothelium-derived vasoconstrictor peptide. Pflugers Arch 413: 108–110CrossRefGoogle Scholar
  167. 163.
    Endo M (1977) Calcium release from the sarcoplasmic reticulum. Physiol Rev 57: 71–108PubMedGoogle Scholar
  168. 164.
    Itoh T, Izumi H, Kuriyama H (1982a) Mechanisms of relaxation induced by activation of β-adrenoceptors in smooth muscle cells of the guinea pig mesenteric artery. J Physiol 326: 475–493PubMedGoogle Scholar
  169. 165.
    Itoh T, Kajiwara M, Kitamura K, Kuriyama H (1982b) Roles of stored calcium on the mechanical response evoked in smooth muscle cells of the porcine coronary artery. J Physiol 322: 107–125PubMedGoogle Scholar
  170. 166.
    Itoh T, Kanmura Y, Kuriyama H (1985) A23187 increases calcium permeability of store sites more than of surface membranes in the rabbit mesenteric artery. J Physiol 359: 467–484PubMedGoogle Scholar
  171. 167.
    Itoh T, Kanmura Y, Kuriyama H, Sumimoto K (1986) A phorbol ester has dual actions on the mechanical response in the rabbit mesenteric and procine coronary arteries. J Physiol 375: 515–534PubMedGoogle Scholar
  172. 168.
    Kobayashi S, Kanaide H, Nakamura M (1985) Cytosolic free calcium transients in cultured vascular smooth muscle cells: Microfluorometric measurements. Science 229: 554–556CrossRefGoogle Scholar
  173. 169.
    lino M (1989) Calcium-induced calcium release mechanism in guinea pig taenia caeci. J Gen Physiol 94: 363–383CrossRefGoogle Scholar
  174. 170.
    lino M (1987) Calcium dependent inositol trisphosphate-induced calcium release in the guinea pig taenia caeci. Biochem Biophys Res Commun 142: 47–52CrossRefGoogle Scholar
  175. 171.
    Takata Y, Kuriyama H (1980) ATP-induced hyperpolarization of smooth muscle cells of the guinea pig coronary artery. J Pharmacol Exp Therap 30: 708–728Google Scholar
  176. 172.
    Furuichi T, Yoshikawa S, Miyawaki A, Wada K, Maeda N, Mikoshiba K (1989) Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein p 400. Nature 342: 32–38PubMedCrossRefGoogle Scholar
  177. 173.
    Kobayashi S, Somlyo AV, Somlyo AP (1988) Heparin inhibits the inositol, 1,4,5-trisphosphate-dependent, but not the independent, calcium release induced by guanine nucleotides in vascular smooth muscle. Biochem Biophys Res Commun 153: 625–631PubMedCrossRefGoogle Scholar
  178. 174.
    Somlyo AP, Walker JW, Goldman YE, Trenthan DR, Kobayashi S, Kitazawa T, Somlyo AV (1988) Inositol trisphosphate, calcium and muscle contraction. Philos Trans R Soc Lond [Biol] 320: 399–414CrossRefGoogle Scholar
  179. 175.
    Eggermont JA, Vrolix M, Wuytack F, Raeymaekers L, Casteels R (1988) The (Ca2+-Mg2+)-ATPase of the plasma membrane and of the endoplasmic reticulum in smooth muscle cells and their regulation. J Cardiovasc Pharmacol 12: 551–555Google Scholar
  180. 176.
    Eggermont JA, Vrolix M, Raeymaekers L, Wuytack F, Casteels R (1988) Ca2+-transport ATPase of vascular smooth muscle. Circ Res 62: 266–278PubMedGoogle Scholar
  181. 177.
    Tada M, Katz AM (1982) Phosphorylation of the sarcoplasmic reticulum and sarcolemma. Annu Rev Physiol 44: 401–423PubMedCrossRefGoogle Scholar
  182. 178.
    Vrolix M, Raeymaekers L, Wuytack F, Hoffmann F, Casteels R (1988) Cyclic GMP-dependent protein kinase stimulates the plasmalemmal Ca2+ pump of smooth muscle via phosphorylation of phosphatidylinositol. Biochem J 255: 855–863PubMedGoogle Scholar
  183. 179.
    Fujiwara T, Itoh T, Kubota Y, Kuriyama H (1988) Action of a phorbol ester on factor regulating contraction in rabbit mesenteric artery. Circ Res 63: 893–902PubMedGoogle Scholar
  184. 180.
    Chatterjee M, Murphy RA (1983) Calcium-dependent stress maintenance without myosin phosphorylation in skinned smooth muscle. Science 221: 464–466PubMedCrossRefGoogle Scholar
  185. 181.
    Chatterjee M, Tejada M (1986) Phorbol ester-induced contraction in chemically skinned vascular smooth muscle. Am J Physiol 251: C892–C803Google Scholar
  186. 182.
    Murphy RA, Mras S (1983) Control of tone in vascular smooth muscle. Arch Intern Med 143: 1001–1006PubMedCrossRefGoogle Scholar
  187. 183.
    Murphy RA, Aksoy MO, Dillon PF, Gerthoffer WT, Kamm KE (1983) The role of myosin light chain phosphorylation in regulation of the cross-bridge cycle. Fed Proc 42: 51–56PubMedGoogle Scholar
  188. 184.
    Kanmura Y, Itoh T, Kuriryama H (1987) Mechanisms of vasoconstriction induced by 9,11-epithio, 11,12-methano-thromboxane A2 in the rabbit coronary artery. Circ Res 60: 402–409PubMedGoogle Scholar
  189. 185.
    Kitamura K, Kuriyama H (1979) Effects of acetylcholine on the smooth muscle cell of isolated main coronary artery of the guinea pig. J Physiol 293: 119–133PubMedGoogle Scholar
  190. 186.
    Suyama A, Kuriyama H (1984) Mechanisms of the ergonovine-induced vasocon striction in the rabbit main coronary artery. Naunyn-Schmiedeberg’s Arch Pharmacol 326: 357–363CrossRefGoogle Scholar
  191. 187.
    Fujii K, Ishimatsu T, Kuriyama H (1986) Vasodilation induced by a-human atrial natriuretic polypeptide in rabbit and guinea pig renal arteries. J Physiol 377: 315–332PubMedGoogle Scholar
  192. 188.
    Sumimoto K, Domae M, Yamanka K, Nakao K, Hashimoto T, Kitamura K, Kuriyama, H. (1980). Actions of nicorandil on vascular smooth muscles. J Cardiovasc Pharmacol 10: S66–S77Google Scholar
  193. 189.
    Popescu LM, Panoiu C, Itinescu M, Nutu O (1985) The mechanism of cyclic GMP-induced relaxation in vascular smooth muscle cells. Eur J Pharmacol 107: 393–394PubMedCrossRefGoogle Scholar
  194. 190.
    Stjärne L (1989) Basic mechanisms and local modulation of nerve impulse-induced secretion of neurotransmitters from individual sympathetic nerve varicosities. Rev Physiol Biochem Pharmacol 112: 1–137PubMedCrossRefGoogle Scholar
  195. 191.
    Rüegg JC (1986) Calcium in muscle activation-A comparative approach. Springer, Berlin HeidelbergGoogle Scholar
  196. 192.
    Yanagisawa T, Kawada M, Taira N (1989) Nitroglycerin relaxes canine coronary arterial smooth muscle without reducing intracellular Ca2+ concentrations measured with fura-2. Br J Pharmacol 98: 469–482PubMedGoogle Scholar
  197. 193.
    Kamm KE, Stull JT (1985) The function of myosin and myosin light chain kinase phosphorylation in smooth muscle. Annu Rev Pharmacol Toxicol 25: 593–620PubMedCrossRefGoogle Scholar
  198. 194.
    Bülbring E, Tomita T (1987) Catecholamine action on smooth muscle. Pharmacol Rev 39: 49–96.PubMedGoogle Scholar
  199. 195.
    Seki S, Suzuki H (1989) Comparison of the prejunctional α,β-adrenoceptor stimulating actions of adrenaline and isoprenaline in the dog mesenteric vein. Br J Pharmacol 97: 1324–1330PubMedGoogle Scholar
  200. 196.
    Kume H, Takai A, Tokuno H, Tomita T (1989) Regulation of Ca2+-dependent K+-channel activity in tracheal myocytes by phosphorylation. Nature 341: 152–154PubMedCrossRefGoogle Scholar
  201. 197.
    Droogmans G, Calleweart G (1986) Ca2+-channel current and its modification by the dihydropuridine agonist Bay K 8644 in isolated smooth musle cells. Pflugers Arch 406: 259–265PubMedCrossRefGoogle Scholar
  202. 198.
    Makita Y, Kanmura Y, Itoh T, Suzuki H, Kuriyama H (1983) Effects of nifedipine derivatives on smooth muscle cells and neuromuscular transmission in the rabbit mesenteric artery. Naunyn Schmiedebergs Arch Pharmacol 324: 302–312PubMedCrossRefGoogle Scholar
  203. 199.
    Terada K, Kitamura K, Kuriyama H (1987a) Blocking actions of Ca2+ antagonists on the Ca2+ channels in smooth muscle cell membrane of rabbit small intestine. Pflugers Arch 408: 552–557PubMedCrossRefGoogle Scholar
  204. 200.
    Terada K, Nakao K, Okabe K, Kitamura K, Kuriyama H (1987) Action of the 1.4-dihydropyridine derivative, KW-3049, on the smooth muscle membrane of the rabbit mesenteric artery. Br J Pharmacol 92: 615–625Google Scholar
  205. 201.
    Terada K, Ohya Y, Kitamura K, Kuriyama H (1987) Actions of flunirizine, a Ca++ antagonist, on ionic currents in fragmented smooth muscle cells of the rabbit small intestine. J Pharmacol Exp Ther 240: 978–983PubMedGoogle Scholar
  206. 202.
    Okabe K, Terada K, Kitamura K, Kuriyama H (1987) Selective and long-lasting inhibitory actions of the dihydropyridine derivative, CV-4093, on calcium currents in smooth muscle cells of the rabbit pulmonary artery J. Pharmacol Exp Ther 243: 703–710Google Scholar
  207. 203.
    Hamilton TC, Weir SW, Weston AH (1986) Comparison of the effects of BRL 34915 and verapamil on electrical and mechanical activity in rat portal vein. Br J Pharmacol 88: 103–111PubMedGoogle Scholar
  208. 204.
    Weir SW, Weston AH (1986) Effects of apamin on response to BRL 34915, nicorandil, and other relaxants in the guinea pig taenia caeci. Br J Pharmacol 88: 113–120PubMedGoogle Scholar
  209. 205.
    Weir SW, Weston AH (1986) The effects of BRL 24915 and nicorandil on electrical and mechanical activity and on 86Rb efflux in rat blood vessels. Br J Pharmacol 88: 121–128PubMedGoogle Scholar
  210. 206.
    Inoue T, Kanmura Y, Fujisawa K, Itoh T, Kuriyama H (1984) Effects of 2-nicotinamidoethyl nitrate (nicorandil; SG-75) and its derivatives on smooth muscle cells of the canine mesenteric artery. J Pharmacol Exp Ther 229: 793–802PubMedGoogle Scholar
  211. 207.
    Yamanaka K, Furukawa K, Kitamura K (1985) The different mechanisms of action of nicorandil and adenosine triphosphate on potassium channels of circular smooth muscle of the guinea pig small intestine. Naunyn Schmiedebergs Arch Pharmacol 331: 96–103PubMedCrossRefGoogle Scholar
  212. 208.
    Gelband CH, Lodge NJ, Van Breemen CV (1989) A Ca2+-activated K+ channel from rabbit aorta: modulation by cromakalim. Eur J Pharmacol 167: 201–210PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • K. Kitamura
  • T. Itoh
  • Y. Ito
  • H. Kuriyama
    • 1
  1. 1.Department of Pharmacology, Faculty of MedicineKyushu UniversityFukuoka, 812Japan

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