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Characteristics and Possible Origins of Blood Velocity Waveforms of the Epicardial and Intramyocardial Coronary Circulation in the Ventricles and the Atria

  • F. Kajiya

Summary

We measured blood velocities in small epicardial coronary arteries and veins of the ventricles and the left atrium, and intramyocardial arteries and veins using our optical-fiber laser Doppler velocimeter which provides excellent access to vessels. The phase opposition of velocity waveforms between coronary arteries and veins was consistent for both left and right ventricles when velocity measurements were performed in a small artery just before its penetration into myocardium, and in a small vein just after its emergence. The phase opposition was more marked in intramyocardial vessels. Diastolic displacement of blood from superficial veins to deeper portions was frequently observed. Atrial contraction caused a transient sharp decrease in arterial flow of the left atrial coronary arteries (systolic dip), and a prominent systolic flow in atrial veins. Thus, the effect of muscle contraction and relaxation on coronary arterial and venous flows may be fundamentally similar in the left and right ventricles, and in the left atrium. The phase opposition indicates the importance of intramyocardial capacitance vessels as a determinant of phasic coronary arterial and venous flows. To investigate the functional characteristics of the intramyocardial capacitance vessels, we analyzed the change in venous flow following changes in coronary arterial inflow. It was shown that during diastole the intramyocardial capacitance vessels have two functional components, unstressed volume and ordinary capacitance. Unstressed volume is defined as the volume of blood in a vessel at zero transmural pressure, and it was approximately 5% of the volume of the myocardium. When the unstressed volume was saturated, the coronary inflow was decreased significantly, compared with that for the unsaturated condition. The systolic coronary venous outflow showed a significant, positive correlation with the total displaceable blood volume stored in the intramyocardial capacitance vessels. Thus, the increase in intramyocardial blood volume decreases the coronary artery inflow, whereas it enhances coronary venous outflow.

Keywords

Left Anterior Descend Blood Flow Velocity Blood Velocity Velocity Waveform Laser Doppler Velocimeter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Porter WT (1898) The influence of the heart-beat on the flow of blood through the walls of the heart. Am J Physiol 1: 145–163Google Scholar
  2. 2.
    Anrep GV, Cruickshank EWH, Downing AC, Sabba RA (1927) The coronary circulation in relation to the cardiac cycle. Heart 14: 111–133Google Scholar
  3. 3.
    Chilian WM, Marcus ML (1984) Coronary venous outflow persists after cessation of coronary arterial inflow. Am J Physiol 247: H984–H990PubMedGoogle Scholar
  4. 4.
    Spaan JAE (1982) Intramyocardial compliance studies by venous outflow at arterial occlusion (abstract). Circulation 66: II–42Google Scholar
  5. 5.
    Kajiya F, Hiramatsu O, Mito K, Tadaoka S, Ogasawara Y, Tsujioka K (1990) Evaluation of coronary blood flow by fiber-optic laser Doppler velocimeter. In: Kajiya F, Klassen GA, Spaan JAE, Hoffman JIE (eds) Coronary circulation. Springer, Tokyo, pp 43–54Google Scholar
  6. 6.
    Tillmanns H, lkeda S, Hansen H, Sarma JSM, Fauvel J-M, Bing RJ (1974) Microcirculation in the ventricle of the dog and turtle. Circ Res 34: 561–569PubMedGoogle Scholar
  7. 7.
    Tillmanns H, Steinhausen M, Leinberger H, Thederan H, Kubler W (1981) Pressure measurements in the terminal vascular bed of the epimyocardium of rats and cats. Circ Res 49: 1202–1211PubMedGoogle Scholar
  8. 8.
    Ashikawa K, Kanatsuka H, Suzuki T, Takishima T (1986) Phasic blood flow velocity pattern in epimyocardial microvessels in the beating canine left ventricle. Circ Res 59: 704–711PubMedGoogle Scholar
  9. 9.
    Kanatsuka H, Lamping KG, Eastham CL, Dellsperger KC, Marcus ML (1989) Comparison of the effects of increased myocardial oxygen consumption and adenosine on the coronary microvascular resistance. Circ Res 65: 1296–1305PubMedGoogle Scholar
  10. 10.
    Nellis SH, Liedtke AJ, Whitesell L (1981) Small coronary vessel pressure and diameter in an intact beating rabbit heart using fixed-position and free-motion techniques. Circ Res 49: 342–353PubMedGoogle Scholar
  11. 11.
    Chilian WM, Eastham CL, Marcus ML (1986) Microvascular distribution of coronary vascular resistance in beating left ventricle. Am J Physiol 251: H779–H788PubMedGoogle Scholar
  12. 12.
    Tanaka T, Benedek GB (1975) Measurement of the velocity of blood flow (in vivo) using a fiber optic catheter and optical mixing spectroscopy. Appl Optics 14:189–196Google Scholar
  13. 13.
    Kajiya F, Hoki N, Tomonaga G, Nishihara H (1981) A laser-Doppler-velocimeter using an optical fiber and its application to local velocity measurement in the coronary artery. Experientia 37: 1171–1173PubMedCrossRefGoogle Scholar
  14. 14.
    Kilpatric D, Linderer T, Sievers RE, Tyberg JV (1982) Measurement of coronary sinus blood flow by fiber-optic laser Doppler anemometry. Am J Physiol 242: H1111–H1114Google Scholar
  15. 15.
    Kajiya F, Mito K, Ogasawara Y, Tsujioka K, Tomonaga G (1984) Laser Doppler blood flow velocimeter with an optical fiber and its applications to detailed measurements of the coronary blood flow velocities. Proc SPIE 494: 25–31Google Scholar
  16. 16.
    Kajiya F, Hiramatsu O, Mito K, Ogasawara Y, Tsujioka K (1987) An optical-fiber laser Doppler velocimeter and its application to measurements of coronary blood flow velocities. Med Prog Technol 12: 77–85PubMedGoogle Scholar
  17. 17.
    Kilpatrick D, Kajiya F, Ogasawara Y (1988) Fibre optic laser Doppler measurement of intravascular velocity. Australas Phys Eng Sci Med 11: 5–14Google Scholar
  18. 18.
    Kajiya F. Tomonaga G, Tsujioka K, Ogasawara Y, Nishihara H (1985) Evaluation of local blood flow velocity in proximal and distal coronary arteries by laser Doppler method. J Biomech Eng 107: 10–15PubMedCrossRefGoogle Scholar
  19. 19.
    Kajiya F, Tsujioka K, Ogasawara Y, Mito K, Hiramatsu O, Goto M, Wada Y, Matsuoka S (1989) Mechanical control of coronary artery inflow and vein outflow. JpnCircJ53: 431–439Google Scholar
  20. 20.
    Chilian WM, Marcus ML (1985) Effects of coronary and extravascular pressure on intramyocardial and epicardial blood velocity. Am J Physiol 248: H 170–H178Google Scholar
  21. 21.
    Hellenbrand WK, Klassen GA, Armour JA, Sezerman O, Paton B (1986) Autonomic nervous system regulation of epicardial coronary vein systolic and diastolic blood velocity as measured by a laser Doppler velocimeter. Can J Physiol Pharmacol 64: 1463–1472PubMedCrossRefGoogle Scholar
  22. 22.
    Gregg DE, Khouri EM, Rayford CR (1965) Systematic and coronary energetics in the resting unanesthetized dog. Circ Res 16: 102–113PubMedGoogle Scholar
  23. 23.
    Lowensohn HS, Khouri EM, Gregg DE, Pyle RL, Patterson RE (1976) Phasic right coronary artery blood flow in conscious dogs with normal and elevated right ventricular pressures. Circ Res 39: 760–766PubMedGoogle Scholar
  24. 24.
    Hiramatsu O, Wada Y, Yamamoto T, Yanaka M, Kimura A, Ogasawara Y, Tsujioka K, Kajiya F (1989) Similar phasic characteristics of artery inflow into and vein outflow from myocardium between left and right ventricles (abstract). Circulation 80: 11–549Google Scholar
  25. 25.
    Kajiya F, Tsujioka K, Ogasawara Y, Hiramatsu O, Wada Y, Goto M, Yanaka M (1989) Analysis of the characteristics of the flow velocity waveforms in left atrial small arteries and veins in the dog. Circ Res 65: 1172–1181PubMedGoogle Scholar
  26. 26.
    Mito K, Ogasawara Y, Hiramatsu O, Wada Y, Goto M, Tadaoka S, Tsujioka K, Kajiya F (1987) Evaluation of velocity waveform in an intramyocardial small artery and vein by laser Doppler method (abstract). Circulation 76: IV–386Google Scholar
  27. 27.
    Mito K, Ogasawara Y, Hiramatsu O, Wada Y, Tsujioka K, Kajiya F (1988) Evaluation of blood flow velocity waveforms in intramyocardial artery and vein by laser Doppler velocimeter with an optical fiber. In: Manabe H, Zweifach BW, Messmer K (eds) Microcirculation in circulatory disorders. Springer, Tokyo, pp 525–528CrossRefGoogle Scholar
  28. 28.
    Hiramatsu O, Mito K, Kajiya, F (1990) Evaluation of the velocity waveform in intramyocardial small vessels. In: Kajiya F, Klassen GA, Spaan JAE, Hoffman JIE (eds) Coronary circulation. Springer, Tokyo, pp 169–172Google Scholar
  29. 29.
    Carew TE, Covell JW (1976) Effect of intramyocardial pressure on the phasic flow in the intraventricular septal artery. Cardiovasc Res 10: 56–64PubMedCrossRefGoogle Scholar
  30. 30.
    Spaan JAE (1985) Coronary diastolic pressure-flow relation and zero flow pressure explained on the basis of intramyocardial compliance. Circ Res 56: 293–309PubMedGoogle Scholar
  31. 31.
    Kajiya F, Tsujioka K, Goto M, Wada Y, Chen X-L, Nakai M, Tadaoka S, Hiramatsu O, Ogasawara Y, Mito K, Tomonaga G (1986) Functional characteristics of intramyocardial capacitance vessels during diastole in the dog. Circ Res 58: 476–485PubMedGoogle Scholar
  32. 32.
    Goto M, Tsujioka K, Ogasawara Y, Wada Y, Tadaoka S, Hiramatsu O, Yanaka M, Kajiya F (1990) Effect of blood filling in intramyocardial vessels on coronary arterial inflow. Am J Physiol 258: H1042–H1048PubMedGoogle Scholar
  33. 33.
    Tsujioka K, Goto M, Hiramatsu O, Wada Y, Ogasawara Y, Kajiya F (1990) Functional characteristics, stics of intramyocardial capacitance vessels and their effects on coronary arterial inflow and venous outflow. In: Kajiya F, Klassen GA, Spaan JAE, Hoffman JIE (eds) Coronary circulation. Springer, Tokyo, pp 89–97Google Scholar

Copyright information

© Springer-Verlag Tokyo 1991

Authors and Affiliations

  • F. Kajiya
    • 1
  1. 1.Department of Medical Engineering and Systems CardiologyKawasaki Medical SchoolKurashiki, Okayama, 701-01Japan

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