Deteriorating Defense Mechanism for Bacterial Infection and High Incidence of Endotoxemia in Surgical Patients Developing MOF
Multiple organ failure (MOF), a clinical concept first reported by Tilney et al. , is a critical state in which the function of vital organs or physiological systems progressively or sequentially deteriorates during hemodialysis for patients with acute renal failure following surgery for a ruptured abdominal aneurysm. Baue , Eiseman et al. , Fry et al. , and others describe similar pathophysiological sequelae which appear in various critically ill patients, including subjects who have undergone gastrointestinal surgery. These authors coincidentally emphasize that most MOF cases are accompanied by severe bacterial infection and that the mortality of MOF is extremely high.
KeywordsMultiple Organ Failure Fresh Freeze Plasma Subtotal Gastrectomy Subtotal Esophagectomy Normal Human Plasma
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- 3.Eisemman B, Beart R, Norton L (1977) Multiple organ failure. Surg Gynecol Obstet 144: 323–326Google Scholar
- 5.Ishiyama M, Watanabe C, Tamakuma S (1984) Clinical aspects of endotoxemia. In: Homma JY, Westphal O et al. (eds) Bacterial endotoxin. Verlag Chemie, Weinheim, pp 307–313Google Scholar
- 8.Watanabe C, Stinnett JD, Alexander JW (1982) Evaluation of serum replacement therapy for bacterial infection in complement-depleted guinea pigs. J Clin Surg 1: 27–31Google Scholar