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Pathophysiology of Acute Embolization of Small Coronary Arteries: Detrimental Effects of Oxygen-Free Radicals

  • Masatsugu Hori
  • Koichi Goto
  • Kunimitsu Iwai
  • Katsuomi Iwakura
  • Yukihiro Koretsune
  • Akira Kitabatake
  • Michitoshi Inoue
  • Takenobu Kamada

Abstract

Recent studies have demonstrated that blood cell plugging occurs after reperfusion of the occluded coronary artery and may impede the perfusion after recanalization [1–4]. Despite the clinical significance of this microcirculatory disturbance, however, the pathophysiology of acute microembolization of coronary vessels is still unclear. We investigated the response of coronary blood flow and histological changes in the myocardium after coronary embolization in dogs and found that the myocardial ischemia induced by coronary embolization is a good ischemic model for assessment of interventions which may influence the ischemic injury. In this study, we attempted to evaluate the role of oxygen-free radicals as a cause of ischemic cell injury in this acute microcirculatory disturbance.

Keywords

Coronary Blood Flow Ischemic Area Hyperemic Response Small Coronary Artery Hyperemic Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Engler RL, Schmid-Schonbein GW, Pavelec RS (1983) Leukocyte capillary plugging in myocardial ischemia and reperfusion in the dog. Am J Pathol 111: 98–111PubMedGoogle Scholar
  2. 2.
    Moschos CB, Lahiri K, Lyons M, Weisse AB, Oldewurtel HA, Regan TJ (1973) Relation of microcirculatory thrombosis to thrombus in the proximal coronary artery: effect of aspirin, dipyridamole, and thrombolysis. Am Heart J 86: 61–68PubMedCrossRefGoogle Scholar
  3. 3.
    Kloner RA, Ganote CE, Jennings RB (1974) The “no-reflow” phenomenon after temporary coronary occlusion in the dog. J Clin Invest 54: 1496–1508PubMedCrossRefGoogle Scholar
  4. 4.
    Leinberger H, Suehiro GT, McNamara JJ (1979) Myocardial platelet trapping after coronary ligation in primates (Papio anubis), platelet trapping in infarct marginal zone. J Surg Research 27: 36–40CrossRefGoogle Scholar
  5. 5.
    Hori M, Inoue M, Kitakaze M, Koretsune Y, Iwai K, Tarnai J, Ito H, Kitabatake A, Sato T, Kamada T (1986) Role of adenosine in hyperemic response of coronary blood flow in microembolization. Am J Phvsiol 250: H509-H518Google Scholar
  6. 6.
    Bing RJ, Castellanos A, Gradel E, Lupton C, Siegel A (1956) Experimental myocardial infarction: circulatory, biochemical and pathologic changes. Am J Med Sci 232: 533–554PubMedCrossRefGoogle Scholar
  7. 7.
    West JW, Kobayashi T, Anderson FS (1962) Effects of selective coronary embolization on coronary blood flow and coronary sinus venous blood oxygen saturation in dogs. Circ Res 10: 722–738PubMedGoogle Scholar
  8. 8.
    Kitakaze M, Hori M, Tarnai J, Iwakura K, Koretsune Y, Kagiya T, Iwai K, Kitabatake A, Inoue M, Kamada T (1987) Alpha1-adrenoceptor activity regulates release of adenosine from the ischemic myocardium in dogs. Circ Res 60: 631–639PubMedGoogle Scholar
  9. 9.
    Hori M, Inoue M, Iwai K, Kitakaze M, Orihashi Y, Kitabatake A, Kamada T (1986) Computer simulation of hyperemic flow in microembolization of coronary arteries. The role of adenosine in patchy myocardial ischemia. Automedica 7: 63–76Google Scholar
  10. 10.
    Gavin JB, Nevalainen TJ, Seelye RN, Webster Y, Thomson RW (1978) An association between the onset of rigor and loss of vascular competence in early myocardial infarcts. Pathology 10: 219–225PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • Masatsugu Hori
    • 1
  • Koichi Goto
    • 1
  • Kunimitsu Iwai
    • 1
  • Katsuomi Iwakura
    • 1
  • Yukihiro Koretsune
    • 1
  • Akira Kitabatake
    • 1
  • Michitoshi Inoue
    • 2
  • Takenobu Kamada
    • 1
  1. 1.First Department of MedicineOsaka University Medical SchoolFukushima-ku, Osaka, 553Japan
  2. 2.Department of Medical Information ScienceOsaka University Medical SchoolFukushima-ku, Osaka, 553Japan

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