Pathophysiology of Acute Embolization of Small Coronary Arteries: Detrimental Effects of Oxygen-Free Radicals
Recent studies have demonstrated that blood cell plugging occurs after reperfusion of the occluded coronary artery and may impede the perfusion after recanalization [1–4]. Despite the clinical significance of this microcirculatory disturbance, however, the pathophysiology of acute microembolization of coronary vessels is still unclear. We investigated the response of coronary blood flow and histological changes in the myocardium after coronary embolization in dogs and found that the myocardial ischemia induced by coronary embolization is a good ischemic model for assessment of interventions which may influence the ischemic injury. In this study, we attempted to evaluate the role of oxygen-free radicals as a cause of ischemic cell injury in this acute microcirculatory disturbance.
KeywordsCoronary Blood Flow Ischemic Area Hyperemic Response Small Coronary Artery Hyperemic Flow
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