Evaluation of the Behavior of Cerebral Blood Flow and Hemorheological Parameters with Infusions of Hydroxyethyl Starch and Low Molecular Weight Dextran in Normal Baboons
The efficacy of hemodilution with an infusion of oncotic plasma substitutes in cerebral ischemia is still controversial , although it is widely performed [2–5]. In general, the infusion with such substances, for example, hydroxyethyl starch (HES) and low molecular weight dextran (LMWD), is known to influence the flow properties of blood markedly by inducing volumetric expansion, i.e., it reduces the flow resistance by decreasing the erythrocyte mass per unit volume and increases the cerebral blood flow (CBF). However, an objective assessment of the rheological behavior associated with changes in CBF over a time-course during and after the infusion of such oncotic substances appears to be necessary to evaluate the efficacy of hemodilution.
KeywordsCerebral Blood Flow Steady State Level Hydroxyethyl Starch Plasma Viscosity Lingual Artery
Unable to display preview. Download preview PDF.
- 4.Wood JH, Simeone FA, Kron RE, Litt M (1982) Rheological aspects of experimental hypervolemic hemodilution with low molecular weight dextran: Relationships of cortical blood flow, cardiac output, and intracranial pressure to fresh blood viscosity and plasma volume. Neurosurgery 11: 739–753PubMedCrossRefGoogle Scholar
- 5.Wood JH, Polyzoidis KS, Epstein CM, Gibby GL, Tindall GT (1984) Quantitative EEG alterations after isovolemic-hemodilutional augmentation of cerebral perfusion in stroke patients. Neurology (Cleveland) 34: 764–768Google Scholar
- 7.Ehrly AM and Landgraf H (1981) Analysis of the specific hemorheological effects of low molecular weight dextran (LMWD)—and saline—infusions in healthy volunteers. Clin Hemorheol 1: 99–109Google Scholar
- 8.Hartmann A, Menzel J, Lange D, Buttinger C (1982) An experimental stroke model to study cerebrovascular responses to chronic regional ischemia. Adv Biosci 43: 167–183Google Scholar