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Evaluation of the Behavior of Cerebral Blood Flow and Hemorheological Parameters with Infusions of Hydroxyethyl Starch and Low Molecular Weight Dextran in Normal Baboons

  • Yoshiyasu Tsuda
  • Alexander Hartmann
  • Jürgen Weiand
  • Laszlo Solymosi
  • Hirohide Matsuo

Abstract

The efficacy of hemodilution with an infusion of oncotic plasma substitutes in cerebral ischemia is still controversial [1], although it is widely performed [2–5]. In general, the infusion with such substances, for example, hydroxyethyl starch (HES) and low molecular weight dextran (LMWD), is known to influence the flow properties of blood markedly by inducing volumetric expansion, i.e., it reduces the flow resistance by decreasing the erythrocyte mass per unit volume and increases the cerebral blood flow (CBF). However, an objective assessment of the rheological behavior associated with changes in CBF over a time-course during and after the infusion of such oncotic substances appears to be necessary to evaluate the efficacy of hemodilution.

Keywords

Cerebral Blood Flow Steady State Level Hydroxyethyl Starch Plasma Viscosity Lingual Artery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Brown MM and Marshall J (1982) Effect of plasma exchange on blood viscosity and cerebral blood flow. Br Med J 284: 1733–1736CrossRefGoogle Scholar
  2. 2.
    Gottstein U and Held K (1969) Effekt der Hamodilution nach intravenöser Infusion von niedermolekularen Dextranen auf die Hirnzirkulation des Menschen. Dtsch Med Wschr 94: 522–526PubMedCrossRefGoogle Scholar
  3. 3.
    Heiss W-D, Prosenz P, Tschabitscher H, Lasek C, Herles HJ (1972) Effect of low molecular dextran on total cerebral blood flow and regional flow within ischemic brain regions. Eur Neurol 8: 129–133PubMedCrossRefGoogle Scholar
  4. 4.
    Wood JH, Simeone FA, Kron RE, Litt M (1982) Rheological aspects of experimental hypervolemic hemodilution with low molecular weight dextran: Relationships of cortical blood flow, cardiac output, and intracranial pressure to fresh blood viscosity and plasma volume. Neurosurgery 11: 739–753PubMedCrossRefGoogle Scholar
  5. 5.
    Wood JH, Polyzoidis KS, Epstein CM, Gibby GL, Tindall GT (1984) Quantitative EEG alterations after isovolemic-hemodilutional augmentation of cerebral perfusion in stroke patients. Neurology (Cleveland) 34: 764–768Google Scholar
  6. 6.
    Harke H, Pieper CH, Meredig J, Rüssler P (1980) Rheologische und gerinnungsphysiologische Untersuchungen nach Infusion von HÄS 200/0.5 und Dextran 40. Anaesthesist 29: 71–77PubMedGoogle Scholar
  7. 7.
    Ehrly AM and Landgraf H (1981) Analysis of the specific hemorheological effects of low molecular weight dextran (LMWD)—and saline—infusions in healthy volunteers. Clin Hemorheol 1: 99–109Google Scholar
  8. 8.
    Hartmann A, Menzel J, Lange D, Buttinger C (1982) An experimental stroke model to study cerebrovascular responses to chronic regional ischemia. Adv Biosci 43: 167–183Google Scholar
  9. 9.
    Agress H, Bacharach SL, Hammock MK, Green MV, Johnson GS, Di Chiro G (1977) Stochastic analysis of 133Xe clearance for determining regional blood flow in a primate model. Stroke 8: 222–226PubMedCrossRefGoogle Scholar
  10. 10.
    Veall N and Mallett BL (1965) The partition of trace amounts of xenon between human blood and brain tissues at 37°C. Phys Med Biol 10: 375–380CrossRefGoogle Scholar
  11. 11.
    Humphrey PRD, Du Boulay GH, Marshall J, Pearson TC, Ross Russel RW, Slater NGP, Symon L, Wetherley-Mein G, Zilkha E (1980) Viscosity, cerebral blood flow and hematocrit in patients with paraproteinemia. Acta Neurol Scand 61: 201–209PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • Yoshiyasu Tsuda
    • 1
    • 2
  • Alexander Hartmann
    • 1
  • Jürgen Weiand
    • 1
  • Laszlo Solymosi
    • 1
  • Hirohide Matsuo
    • 2
  1. 1.Neurological and Neuroradiological University Clinic of BonnBonn 1Federal Republic of Germany
  2. 2.Second Department of Internal MedicineKagawa Medical UniversityMiki-cho, KagawaJapan

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