Analysis of Diameter and Flow Velocity Changes in Small Pulmonary Vessels During Regional Alveolar Hypercapnia

  • Mikiyasu Shirai
  • Kouji Sada
  • Ishio Ninomiya


Effects of alveolar hypercapnia on the pulmonary vessels have been studied chiefly by measuring the pressure-flow relationship [1–3]. Some of the results have suggested an increase in the vascular resistance to blood flow in the hypercapnic lung area [1, 2], whereas others have not [3]. However, we consider that for detecting the local pulmonary vasomotion during alveolar hypercapnia, it is necessary to measure directly the internal diameter (ID) of small pulmonary vessels with rich smooth muscle layers. In this study, using a new X-ray TV system developed in our laboratory [4], we quantitatively analyzed the changes in 10 of the small pulmonary arteries and veins (100–600 μm 10) in unilobar alveolar hypercapnia. Simultaneously, flow velocity and volume flow in the small arteries were analyzed.


Internal Diameter Volume Flow Small Artery Lower Lung Small Pulmonary Artery 
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  1. 1.
    Hyman AL, Kadowitz PJ (1975) Effects of alveolar and perfusion hypoxia and hypercapnia on pulmonary vascular resistance in the lamb. Am J Physiol 228: 397–403PubMedGoogle Scholar
  2. 2.
    Manfredi F, Sieker HO (1960) The effect of carbon dioxide on the pulmonary circulation. J Clin Invest 39: 295–301PubMedCrossRefGoogle Scholar
  3. 3.
    Peters RM (1957) Effect of unilateral carbon dioxide breathing on pulmonary blood flow. Am J Physiol 191: 399–403PubMedGoogle Scholar
  4. 4.
    Sada K, Shirai M, Ninomiya I (1985) X-ray TV system for measuring microcirculation in small pulmonary vessels. J Appl Physiol 59: 1013–1018PubMedGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • Mikiyasu Shirai
  • Kouji Sada
  • Ishio Ninomiya
    • 1
  1. 1.Department of Cardiac PhysiologyNational Cardiovascular Center Research InstituteSuita, Osaka, 565Japan

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