Abstract
Erythrocyte aggregation is induced in blood flowing at low shear rates, especially in the stasis of blood, by macromolecular bridging between adjacent erythrocytes [1]. The process of erythrocyte aggregation is reversible; aggregates disintegrate at high shear rates. Since the facilitation of erythrocyte aggregation reduces the blood flow, the kinetic analysis of erythrocyte aggregation is very important for understanding the control of blood flow, rheologically. This paper describes a method for measuring the velocity of erythrocyte aggregation and the effect of immunoglobulin G and related macromolecules on the velocity.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Chien S, Jan K-M (1973) Ultrastructural basis of the mechanism of rouleau formation. Microvasc Res 5: 155–166
Maeda N, Sekiya M, Kameda K, Shiga T (1986) Effect of immunoglobulin preparations on the aggregation of human erythrocytes. Eur J Clin Invest 16: 184–191
Imaizumi K, Shiga T (1983) Effect of immunoglobulins and IgG-fragments on the human erythrocyte aggregation, studied by a rheoscope combined with image analyzer. Biorheology 20: 569–577
Schmid-Schönbein H, Wells R, Schildkraut R (1969) Microscopy and viscometry of blood flowing under uniform shear rate (rheoscope). J Appl Physiol 26: 674–678
Shiga T, Imaizumi K, Harada N, Sekiya M (1983) Kinetics of rouleaux formation using TV-image analyzer: I. Human erythrocytes. Am J Physiol 245: H252-H258
Valentine RC, Green NM (1967) Electron microscopy of an antibody-hapten complex. J Mol Biol 27: 615–617
Edelman GM, Heremans JF, Heremans M-T, Kunkel HG (1960) Immunological studies of human γ-globulin. Relation of the precipitin lines of whole γ-globulin to those of the fragments produced by papain. J Exp Med 112: 203–223
Maeda N, Shiga T (1986) Opposite Effect of albumin on the erythrocyte aggregation induced by immunoglobulin G and fibrinogen. Biochim Biophys Acta 855: 127–135
Imaizumi K, Imai A, Maruyama T, Shiga T (1984) Inhibition of IgG-, F(ab′h)2- and myeloma protein-induced erythrocyte aggregation, by small Ig G-fragments. Clin Hemorheol 4: 431–439
Maeda N, Shiga T (1985) Inhibition and acceleration of erythrocyte aggregation induced by small macromolecules. Biochim Biophys Acta 843: 128–136
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Tokyo
About this chapter
Cite this chapter
Maeda, N., Seike, M., Imaizumi, K., Kon, K., Shiga, T. (1988). Erythrocyte Aggregation Induced by Immunoglobulin G and Related Macromolecules Studied with Rheoscope-Image Analyzer-Computer System. In: Manabe, H., Zweifach, B.W., Messmer, K. (eds) Microcirculation in Circulatory Disorders. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68078-9_58
Download citation
DOI: https://doi.org/10.1007/978-4-431-68078-9_58
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68080-2
Online ISBN: 978-4-431-68078-9
eBook Packages: Springer Book Archive