Erythrocyte Aggregation Induced by Immunoglobulin G and Related Macromolecules Studied with Rheoscope-Image Analyzer-Computer System

  • Nobuji Maeda
  • Masahiko Seike
  • Kazuhiko Imaizumi
  • Kazunori Kon
  • Takeshi Shiga


Erythrocyte aggregation is induced in blood flowing at low shear rates, especially in the stasis of blood, by macromolecular bridging between adjacent erythrocytes [1]. The process of erythrocyte aggregation is reversible; aggregates disintegrate at high shear rates. Since the facilitation of erythrocyte aggregation reduces the blood flow, the kinetic analysis of erythrocyte aggregation is very important for understanding the control of blood flow, rheologically. This paper describes a method for measuring the velocity of erythrocyte aggregation and the effect of immunoglobulin G and related macromolecules on the velocity.


Shear Rate Human Erythrocyte High Shear Rate Erythrocyte Aggregation Autologous Plasma 
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Copyright information

© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • Nobuji Maeda
  • Masahiko Seike
  • Kazuhiko Imaizumi
  • Kazunori Kon
  • Takeshi Shiga
    • 1
  1. 1.Department of Physiology, School of MedicineEhime UniversityShigenobu, Onsengun, EhimeJapan

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