Regulation of Plasma Membrane Ca-Pump ATPase of Vascular Smooth Muscle by cGMP
Relaxation of vascular smooth muscle can be induced by several agents, such as nitrovasodilators, natriuretic factor, and endothelium-derived relaxant factor (EDRF), which increase the cyclic guanosine monophosphate (cGMP) level within vascular smooth muscle cells (VSMCs; Fig. 1) [1, for review]. There is a good parallel between the cGMP accumulation and reduction of vascular tone [1,2]. cGMP-dependent protein kinase (G-PK) phosphorylates several proteins in VSMCs . However, the function of these proteins and their relevance to vasodilation remain unclear. The Ca-pump ATPase in the plasma membrane of VSMCs presumably plays an important role in the relaxation of VSMCs through its A TP- and calmodulin-dependent Ca2+ extrusion. Therefore, we examined whether the plasma membrane Ca pump is a target for G-PK-dependent regulation.
KeywordsVascular Smooth Muscle Cyclic Guanosine Monophosphate Good Parallel Phospholipid Liposome cGMP Accumulation
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