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Regulation of Plasma Membrane Ca-Pump ATPase of Vascular Smooth Muscle by cGMP

  • Ken-Ichi Furukawa
  • Yuko Tawada
  • Hiroshi Nakamura
  • Munekazu Shigekawa

Abstract

Relaxation of vascular smooth muscle can be induced by several agents, such as nitrovasodilators, natriuretic factor, and endothelium-derived relaxant factor (EDRF), which increase the cyclic guanosine monophosphate (cGMP) level within vascular smooth muscle cells (VSMCs; Fig. 1) [1, for review]. There is a good parallel between the cGMP accumulation and reduction of vascular tone [1,2]. cGMP-dependent protein kinase (G-PK) phosphorylates several proteins in VSMCs [3]. However, the function of these proteins and their relevance to vasodilation remain unclear. The Ca-pump ATPase in the plasma membrane of VSMCs presumably plays an important role in the relaxation of VSMCs through its A TP- and calmodulin-dependent Ca2+ extrusion. Therefore, we examined whether the plasma membrane Ca pump is a target for G-PK-dependent regulation.

Keywords

Vascular Smooth Muscle Cyclic Guanosine Monophosphate Good Parallel Phospholipid Liposome cGMP Accumulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • Ken-Ichi Furukawa
  • Yuko Tawada
  • Hiroshi Nakamura
  • Munekazu Shigekawa
    • 1
  1. 1.Department of Molecular PhysiologyNational Cardiovascular Center Research InstituteSuita, Osaka, 565Japan

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