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The Interaction of Immune Complexes in Microcirculatory Impairment in Patients with Vasculitis

  • Terence J. Ryan

Abstract

Vasculitis is an inflammatory response as a consequence of injury to small vessels. However, a concept popular during the past decade is that vasculitis is an immunological response, but many factors other than immunological processes are responsible for the final pathology and clinical picture of vasculitis [1, 2]. The injury done to blood vessels produces changes in their perfusion, damage to the endothelium with exhaustion of many of its functions, leakiness so that materials of all kinds can finally escape into the tissues, and during the process of repair, angiogenesis gives rise to abnormal or changed vascular patterns [3].

Keywords

Immune Complex Immunological Process Elastin Fibre Microvascular Injury Poor Perfusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Ryan TJ (ed) (1976) Microvascular injury, Major problems in dermatology, vol. 7. Lloyd Luke, London.Google Scholar
  2. 2.
    Ryan TJ, Wilkinson DS (1986) Vasculitis and angiitis. In: Rook A, Wilkinson DS, Ebling FJG, Champion RH, Burton JL (eds) Textbook of dermatology, 4th edn. Blackwell, Oxford, pp 1121–1185Google Scholar
  3. 3.
    Ryan TJ (1980) Anatomical features relevant to vasculitis. In: Wolff K, Winkelmann RK (eds) Vasculitis. Major problems in dermatology, vol. 10. Lloyd Luke, London, pp 25–30Google Scholar
  4. 4.
    Ueki H, Masuda T (1982) Immune complex and cutaneous disease. Dermatology (Japan) 9: 255–264Google Scholar
  5. 5.
    Kanan MW, Ryan TJ (1976) Localisation of granulomatous diseases and vasculitis in the nasal mucosa. In: Ryan TJ (ed) Microvascular injury. Major problems in dermatology, vol. 7. Lloyd Luke, London, pp 195–220Google Scholar
  6. 6.
    Willms-Kretschmer K, Majno G (1969) Ischaemia of the skin. Am J Pathol 54: 327–343PubMedGoogle Scholar
  7. 7.
    Kanan MJ (1975) The biological behaviour of the nasal mucosa towards blood borne particulate matter. D. Phil Thesis, Oxford UniversityGoogle Scholar
  8. 8.
    Miyachi Y, Yanase K, Imamura S, Niwa Y (1982) Increased hydroxyl radical generation by normal polymorphonuclear leukocytes incubated in sera from patients with leukocytoclastic vasculitis. Arch Dermatol Res 274: 65–71PubMedCrossRefGoogle Scholar
  9. 9.
    Joselow SA, Gown A, Mannik M (1985) Cutaneous deposition of immune complexes in chronic serum sickness of mice induced with cationized or unaltered antigen. J Invest Dermatol 85: 559–563PubMedCrossRefGoogle Scholar
  10. 10.
    Hauck G (1982) The connective tissue space in view of Iymphology. Experientia 38: 1121–1122PubMedCrossRefGoogle Scholar
  11. 11.
    Parish WE (1985) Cutaneous elastin degradation in ageing and inflammation. J Appl Cosmetol 3: 187–210Google Scholar
  12. 12.
    Hsu PS, Izaki S, Hibino T, Izaki M (1986) Elastase activity in granulomatous inflammation in experimental murine leprosy. Exp Mol Pathol 45: 84–92PubMedCrossRefGoogle Scholar
  13. 13.
    De Long TG, Simmons RL (1982) Role of lymphatic vessels in bacterial clearance from early soft-tissue infection. Arch Surg 117: 123–128CrossRefGoogle Scholar
  14. 14.
    Ryan TJ, Mortimer PS, Jones RL (1986) Lymphatics of the skin: neglected but important. Int J Dermatol 10: 411–417CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • Terence J. Ryan
    • 1
  1. 1.Department of DermatologySlade HospitalHeadington, OxfordEngland

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