Microvascular Permeability: Its Disturbance in Disease

  • Laurence H. Smaje


The main function of the microcirculation is exchange. In order to fulfill this role, material must be brought to the microvasculature by convection and then be transported across the permeable portions of the capillary wall to the tissues by a mixture of convection and diffusion.


Essential Hypertension Capillary Pressure Vasoconstrictor Response Autonomic Neuropathy Combine Oral Contraceptive 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Lassen NA, Parving H-H, Rossing N (1974) Filtration as the main mechanism of overall transcapillary protein escape from the plasma. Microvasc Res 7: 1–4CrossRefGoogle Scholar
  2. 2.
    Hassan A, Carter G, Tooke JE (1986) Postural vasoconstriction in the human foot during the menstrual cycle. J Physiol 382: 44PGoogle Scholar
  3. 3.
    Henriksen O, Sejrsen P (1976) Local reflex in microcirculation in human cutaneous tissue. Acta Physiol Scand 98: 227–231PubMedCrossRefGoogle Scholar
  4. 4.
    Noddeland H, Aukland K, Nicolaysen G (1981) Plasma colloid osmotic pressure in venous blood from the human foot in orthostasis. Acta Physiol Scand 113: 447–454PubMedCrossRefGoogle Scholar
  5. 5.
    Hassan AAK, Tooke JE (1988) Effect of combined oral contraceptive therapy on the postural vasoconstrictor response in the human foot. Postgrad Med J (in press)Google Scholar
  6. 6.
    Tooke JE (1987) The microcirculation in diabetes. Diabetic Medicine 4: 189–196PubMedCrossRefGoogle Scholar
  7. 7.
    Rayman G, Hassan A, Tooke JE (1986) Blood flow in the skin ofthe foot related to posture in diabetes mellitus. Br Med J 292: 87–90CrossRefGoogle Scholar
  8. 8.
    Michel CC, Moyses C (1987) The measurement of fluid filtration in human limbs. In: Tooke JE, Smaje LH (eds) Clinical investigation of the microcirculation. Martinus Nijhoff, Boston, pp 103–126CrossRefGoogle Scholar
  9. 9.
    Trap-Jensen J, Alpert JC, Garcia del Rio H, Lassen NA (1967) Capillary diffusion capacity for sodium in skeletal muscle in long-term juvenile diabetes mellitus. Acta Med Scand [Suppl] 476: 135–146Google Scholar
  10. 10.
    Williamson JR, Vogler NJ, Kilo C (1969) Estimation of vascular basement membrane thickness. Diabetes 18: 567–578PubMedGoogle Scholar
  11. 11.
    Tooke JE (1980) A capillary pressure disturbance in young diabetics. Diabetes 29: 815–819PubMedCrossRefGoogle Scholar
  12. 12.
    Eichna LW, Bordley J (1942) Capillary blood pressure in man. Direct measurements in the digits of normal and hypertensive subjects during vasoconstriction and vasodilatation. J Clin Invest 21: 711–729PubMedCrossRefGoogle Scholar
  13. 13.
    Parving HH, Gyntelberg F (1973) Transcapillary escape rate of albumin and plasma volume in essential hypertension. Circ Res 32: 643–651PubMedGoogle Scholar
  14. 14.
    Parving HH, Jensen AE, Westrup M (1977) Increased transcapillary escape rate of albumin and IgG in essential hypertension. Scand J Clin Lab Invest 37: 223–227PubMedCrossRefGoogle Scholar
  15. 15.
    Williams SA, Boolell M, MacGregor GA, Smaje LH, Wasserman S, Tooke JE (1988) Capillary hypertension in subjects with essential hypertension. (submitted)Google Scholar

Copyright information

© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • Laurence H. Smaje
    • 1
  1. 1.Department of Physiology, Charing Cross and Westminster Medical SchoolUniversity of LondonLondonEngland

Personalised recommendations