Nonesterified Fatty Acid Metabolism and Membrane Disorders in Myocardial Ischemia and Reperfusion
Under normal circumstances, 40%–60% of the circulatory non esterified fatty acids (NEFAs) are extracted from the heart in a single transit time . The majority of NEFAs are oxidized in the mitochondria for energy delivery. Such NEF As as arachidonic acid, linoleic acid, and docosahexaenoic acid are mainly incorporated into phospholipids, a major constituent of cell membranes. In this respect, species differences and the effect of nutrition have to be appreciated. For example, in the dog, myocyte membranes mainly consist of arachidonic acid and linoleic acid, while membrane lipids of rat myocytes mainly consist of arachidonic acid and docosahexaenoic acid.
KeywordsArachidonic Acid Myocardial Fatty Acid Nonesterified Fatty Acid Free Arachidonic Acid High Relative Increase
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