Changes in Coronary Microcirculation in Acute Ischemia

  • Takashi Yamakawa
  • Saburo Yamaguchi
  • Hideyuki Niimi


Blood cells flowing in the coronary microvascular network are responsible for oxygen supply to myocardial cells. Among these cells, white cells (WBCs) are more spherical, larger, and less deformable than red cells (RBCs) [1]. For this reason, WBCs may have an important influence on the microcirculation, especially at a low perfusion pressure. In fact, according to intravital microscopic observation of microcirculation in the s~eletal muscle, one or several WBCs may block the capillary flow during hemorrhagic shock [2]. There is also histological evidence that WBC plugging may cause mechanical obstruction of coronary capillaries in myocardial ischemia [3].


Hemorrhagic Shock Capillary Flow Acute Ischemia Coronary Microcirculation Light Pipe 
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Copyright information

© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • Takashi Yamakawa
  • Saburo Yamaguchi
  • Hideyuki Niimi
    • 1
  1. 1.National Cardiovascular Center Research InstituteSuita, Osaka, 565Japan

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