Maintenance of Constant Cerebral Blood Volume by Veni-Arterial Reflex

  • George Mchedlishvili


The constancy of cerebral blood volume (CBV) was originally conjectured to be dependent solely upon mechanical factors, e.g., the rigidity of the skull, incompressibility of intracranial ingredients. Subsequently, however, a physiological regulatory mechanism was discovered to be responsible for active maintenance of constant CBV [1]. This physiological mechanism was first found under experimental conditions when the CBV was increased and the resistance in major arteries of the brain was simultaneously monitored. A significant increase in CBV was easily achieved in animal experiments, whereby a large opening was made in the skull and the hyperemic brain could readily expand out of the hole.


Vertebral Artery Cerebral Blood Volume Systemic Arterial Pressure Cerebral Vein Major Artery 
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  1. 1.
    Mchedlishvili G (1986) Arterial behavior and blood circulation in the brain. Plenum, New YorkGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • George Mchedlishvili
    • 1
  1. 1.Microcirculation Research Center, I. Beritashvili Institute of PhysiologyGeorgian Academy of SciencesTbilisiUSSR

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