Role of Oxygen Free Radicals in Focal Brain Ischemia

  • Reginald J. Davis
  • Gregory B. Bulkley
  • Richard J. Traystman


Oxygen-derived free radicals have been implicated in a wide variety of disease states [1,2] and have been postulated to mediate an element of cerebral ischemic injury. We tested the hypothesis that neutralization of oxygen free radicals using superoxide dismutase (SOD) ameliorates the cerebral ischemic injury produced by temporary occlusion of the middle cerebral artery.


Cerebral Blood Flow Middle Cerebral Artery Middle Cerebral Artery Occlusion Somatosensory Evoke Potential Left Middle Cerebral Artery 
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  1. 1.
    Fridovich I (1978) The biology of oxygen radicals. Science 201: 875–880PubMedCrossRefGoogle Scholar
  2. 2.
    Weiss SJ (1986) Oxygen, ischemia and inflammation. In: Del Maestro RF, Arfors KE (eds) Free radicals in microcirculation. Acta Physiol Scand [Suppl] 548: 9–37Google Scholar

Copyright information

© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • Reginald J. Davis
    • 1
  • Gregory B. Bulkley
    • 2
  • Richard J. Traystman
    • 3
  1. 1.Departments of NeurosurgeryThe Johns Hopkins Medical InstitutionsBaltimoreUSA
  2. 2.Departments of SurgeryThe Johns Hopkins Medical InstitutionsBaltimoreUSA
  3. 3.Departments of Anesthesiology/Critical MedicineThe Johns Hopkins Medical InstitutionsBaltimoreUSA

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