Endothelium-Dependent Relaxing Factors in Brain Microvessels

  • William I. Rosenblum


A pathological decrease in local or general cerebral blood flow may have many causes, several of which can act at the same time. In recent years, a significant addition has been made to the number of ways by which the flow may be increased. This addition is the result of a new discovery concerning the importance of endothelial cells in some forms of vasodilation. The new understanding began with the discovery that acetylcholine (ACh) produces dilation in many blood vessels, not by activating muscarinic receptors in vascular smooth muscle, but by activating such receptors in the endothelium. The endothelium in turn produces and releases a relaxing factor that penetrates the muscle and produces relaxation. This substance has become known as endothelium-dependent relaxing factor (EDRF). This entire area has been extensively reviewed [1–4], and the evidence for multiple EDRFs has been supported by additional publications [5–7].


Sodium Nitroprusside Sodium Fluorescein Endothelium Derive Relaxant Factor Baseline Diameter Cerebral Microcirculation 
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Copyright information

© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • William I. Rosenblum
    • 1
  1. 1.Neuropathology, Medical College of VirginiaVirginia Commonwealth UniversityRichmondUSA

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