Role of the Hepatic Microcirculation in the Pathogenesis and Development of Alcoholic Liver Disease: Possible Involvement of Hyper-catecholaminemia in Alcoholic Liver Damage
The effect of adrenaline on the hepatic microcirculation and hepatic oxygenation was investigated in normal and alcoholic rats. The intraperitoneal administration of adrenaline (0.25-mg, 0.5-mg/kg body weight) to rats decreased regional hepatic hemoglobin (Hb) concentration, an index of regional hepatic blood volume, and reduced the oxygen saturation of Hb in the regional hepatic tissue. A rise of serum glutamic-pyruvic transaminase (GPT) activity resulted. The reduction of hepatic Hb oxygenation was closely correlated with an elevation of serum GPT activity.
The adrenaline treatment caused a remarkable drop in sinusoidal blood flow velocity in hepatic lobules as measured by a TV monitor using the dual-slit photometric method.
The chronically ethanol-treated rats (20% ethanol for 3 months) showed a more severe hepatic hypoxia and higher elevation of serum GPT level in response to adrenaline treatment than normal control rats.
These findings support the possible involvement of hypercatecholaminemia in the development and progression of alcoholic liver damage through microcirculatory disturbance.
KeywordsHepatic Tissue Intraperitoneal Administration Hepatic Microcirculation Reflectance Spectrophotometry Serum Free Fatty Acid Level
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