Leukocyte Adherence in Hepatic Microcirculation in Ischemia Reperfusion
The pathophysiological problem of ischemia and reperfusion in the liver is clinically encountered in liver transplantation  and in hemorrhagic shock . Vascular complications of liver transplantation occur in the early postoperative period and are unrelated to graft rejection, which may occur at a later stage. To understand the underlying pathogenetic mechanisms, it is important to consider the following two conditions. First, the donor liver is not perfused by blood and is an ischemic organ during storage. Second, the transplanted liver is reperfused after the surgical anastomoses of blood vessels have been completed. Thus, the liver transplant undergoes the pathophysiological consequences of ischemia and reperfusion. Similarly, in circulatory shock, the liver is rendered ischemic, and reperfusion occurs when the systemic hypotension is corrected.
KeywordsIschemia Reperfusion Acridine Orange Leukocyte Adherence American Optical Video Monitor
Unable to display preview. Download preview PDF.
- 3.Arfors KE (1986) Free radicals in microcirculation. Acta Physiol Scand Suppl 548: 7Google Scholar
- 6.Koo A (1984) Current methods and concepts on the visceral microcirculation. Prog Appl Microcirc 6: 54–68Google Scholar
- 10.Warner NE, Bunnag S, Bunnag SC (1965) Microcirculation of the islets of Langerhans in experimental endotoxemia in mice. Biblthca Anat 7: 449–452Google Scholar