Leukocyte Adherence in Hepatic Microcirculation in Ischemia Reperfusion

  • Anthony Koo
  • Gregory Breit
  • Marcos Intaglietta


The pathophysiological problem of ischemia and reperfusion in the liver is clinically encountered in liver transplantation [1] and in hemorrhagic shock [2]. Vascular complications of liver transplantation occur in the early postoperative period and are unrelated to graft rejection, which may occur at a later stage. To understand the underlying pathogenetic mechanisms, it is important to consider the following two conditions. First, the donor liver is not perfused by blood and is an ischemic organ during storage. Second, the transplanted liver is reperfused after the surgical anastomoses of blood vessels have been completed. Thus, the liver transplant undergoes the pathophysiological consequences of ischemia and reperfusion. Similarly, in circulatory shock, the liver is rendered ischemic, and reperfusion occurs when the systemic hypotension is corrected.


Ischemia Reperfusion Acridine Orange Leukocyte Adherence American Optical Video Monitor 
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Copyright information

© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • Anthony Koo
    • 1
    • 2
  • Gregory Breit
    • 3
  • Marcos Intaglietta
    • 3
  1. 1.Department of MedicineUniversity of CaliforniaLos AngelesUSA
  2. 2.School of Medicine, Center for Ulcer Research and EducationV.A. Wadsworth Medical CenterLos AngelesUSA
  3. 3.Department of AMES-BioengineeringUniversity of CaliforniaSan Diego, La JollaUSA

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