Metabolic and Myogenic Control of Gastric Mucosal Blood Flow
Previous studies of local circulatory control in the stomach showed that total gastric blood flow is regulated by metabolic and possibly myogenic mechanisms [1–3]. However, because of the limitations of previously available blood flowmeasuring techniques, similar studies have not been extended to the gastric mucosa. Given the heterogeneity of the gastric circulation and the functional stratification of the gastric wall, it is possible that blood flow within the different layers of the stomach may be regulated independently and possibly by different mechanisms. This possibility is supported by our recent demonstration of mucosal blood flow autoregulation in the absence of autoregulation of total blood flow . We designed the present study to identify the mechanism responsible for the pronounced autoregulation of gastric mucosal blood flow and determine whether metabolic or myogenic mechanisms regulate the mucosal circulation.
KeywordsPerfusion Pressure Mucosal Blood Flow Gastric Mucosal Blood Flow American Gastroenterological Association Myogenic Response
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