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Metabolic and Myogenic Control of Gastric Mucosal Blood Flow

  • J. W. Kiel
  • G. L. Riedel
  • A. P. Shepherd

Abstract

Previous studies of local circulatory control in the stomach showed that total gastric blood flow is regulated by metabolic and possibly myogenic mechanisms [1–3]. However, because of the limitations of previously available blood flowmeasuring techniques, similar studies have not been extended to the gastric mucosa. Given the heterogeneity of the gastric circulation and the functional stratification of the gastric wall, it is possible that blood flow within the different layers of the stomach may be regulated independently and possibly by different mechanisms. This possibility is supported by our recent demonstration of mucosal blood flow autoregulation in the absence of autoregulation of total blood flow [4]. We designed the present study to identify the mechanism responsible for the pronounced autoregulation of gastric mucosal blood flow and determine whether metabolic or myogenic mechanisms regulate the mucosal circulation.

Keywords

Perfusion Pressure Mucosal Blood Flow Gastric Mucosal Blood Flow American Gastroenterological Association Myogenic Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Holm-Rutilli L, Perry MA, Granger DN (1981) Autoregulation of gastric blood flow and oxygen uptake. Am J Physiol 241: G143–G149Google Scholar
  2. 2.
    Perry MA, Murphree D, Granger DN (1982) Oxygen uptake as a determinant of gastric blood flow autoregulation. Dig Dis Sci 27: 675–679PubMedCrossRefGoogle Scholar
  3. 3.
    Lutz J, Biester J (1971) Die Reaktion der Magengefäße auf venöse und arterielle Druckreize und ihr Vergleich mit Werten von Milz- und Intestinalstrombahn. Plügers Arch 330: 230–242CrossRefGoogle Scholar
  4. 4.
    Kiel JW, Riedel GL, Shepherd AP (1987) Autoregulation of canine gastric mucosal blood flow. Gastroenterology 93: 12–20PubMedGoogle Scholar
  5. 5.
    Moody FG, Durbin RP (1965) Effects of glycine and other instillates on concentration of gastric acid. Am J Physiol 209: 122–126PubMedGoogle Scholar
  6. 6.
    Bonner R, Nossal R (1981) Model for laser-Doppler measurements of blood flow in tissue. Appl Opt 20: 2097–2107PubMedCrossRefGoogle Scholar
  7. 7.
    Kiel JW, Riedel GL, Di Resta GR, Shepherd AP (1985) Gastric mucosal blood flow measured by laser-Doppler velocimetry. Am J Physiol 249: G539–G545PubMedGoogle Scholar
  8. 8.
    Norris CP, Barnes GE, Smith EE, Granger HJ (1979) Autoregulation of superior mesenteric flow in fasted and fed dogs. Am J Physiol 237: HI74–HI77Google Scholar
  9. 9.
    Shepherd AP, Granger HJ (1973) Autoregulatory escape in the gut: a systems analysis. Gastroenterology 65: 77–91PubMedGoogle Scholar
  10. 10.
    Folkow B (1964) Description of the myogenic hypothesis. Circ Res 14 (Suppl. 1): 279–285Google Scholar
  11. 11.
    Johnson PC (1965) Effect of venous pressure on mean capillary pressure and vascular resistance in the intestine. Circ Res 16: 294–300PubMedGoogle Scholar
  12. 12.
    Shepherd AP (1977) Myogenic responses of intestinal resistance and exchange vessels. Am J Physiol 233: H547–H554PubMedGoogle Scholar
  13. 13.
    Kiel JW, Riedel GL, Shepherd AP (1987) Local control of canine gastric mucosal blood flow. Gastroenterology 93: 1041–1053PubMedGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • J. W. Kiel
  • G. L. Riedel
  • A. P. Shepherd
    • 1
  1. 1.Department of PhysiologyUniversity of Texas Health Science CenterSan AntonioUSA

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