Skip to main content
SpringerLink
Log in

Gastric Microcirculatory Changes Associated with Physicochemical and Ionic Mediators

  • Chapter
Book cover Microcirculation in Circulatory Disorders

  • 75 Accesses

Abstract

The mechanism of stress-induced acute gastric mucosal lesions (AGML) has been investigated for some time. We have reported that in hemorrhagic shock, the decrease of gastric mucosal blood flow, volume, and its oxygenation precedes the gastric ulceration which appears usually after infusion of blood or at the recovery stage in rats and humans. It is believed that the microcirculatory disturbance resulting in hypoxia in the gastric mucosa produced an incipient mucosal state for ulcerogenesis and that in this hydrochloric acid and histamine played an aggressive role. The precise mechanism leading to cell death after ischemia is, however, obscure. In this symposium, we presented a movie film which showed the process of gastric mucosal microcirculatory disturbance and bleeding caused by indomethacin, leukotriene C4 (LTC4), platelet-activating factor (PAF) and HCI and also reported the role of chemical and ionic factors in the repefusion state in the etiology of gastric ulceration.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Sato N, Kamada T, Shichiri M, Kawano S, Abe H, Hagihara B (1979) Measurement of hemoperfusion and oxygen sufficiency in gastric mucosa in vivo. Gastroenterology 76: 814–819

    PubMed  CAS  Google Scholar 

  2. Kamada T, Sato N, Kawano S, Fusamoto H, Abe H (1982) Gastric mucosal hemodynamics after thermal or head injury. Gastroenterology 83: 535–540

    PubMed  CAS  Google Scholar 

  3. Sato N, Kawano S, Kamada T, Takeda M (1986) Hemodynamics of the gastric mucosa and gastric ulceration in rats and in patients with gastric ulcer. Dig Dis Sci 31: 35S–41S

    Article  PubMed  CAS  Google Scholar 

  4. Hase T, Moss BJ (1973) Microvascular changes of gastric mucosa in the development of stress ulcer in rats. Gastroenterology 65: 224–234

    PubMed  CAS  Google Scholar 

  5. Szabo S, Trier JS, Brown A, Schnoor J (1985) Early vascular injury and increased vascular permiability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology 88: 228–236

    PubMed  CAS  Google Scholar 

  6. Itoh M, Guth PH (1985) Role of oxygen-derived free radicals in hemorrhagic shockinduced gastric lesions in the rat. Gastroenterology 88: 1162–1167

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. First Department of Medicine, Osaka University Medical School, 1-50, Fukushima 1-chome, Fukushima-ku, Osaka 553, Japan

    Sunao Kawano, Nobuhiro Sato, Shingo Tsuji & Takenobu Kamada

  2. Central Research Division, Takeda Chemical Industries Ltd, 17-85, Juso-honmachi 2-chome, Yodogawa-ku, Osaka 532, Japan

    Hiroshi Satoh & Nobuhiro Inatomi

Authors
  1. Sunao Kawano
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nobuhiro Sato
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shingo Tsuji
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Takenobu Kamada
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hiroshi Satoh
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Nobuhiro Inatomi
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. National Cardiovascular Center of Japan, Suita, Osaka, 565, Japan

    Hisao Manabe M.D. (President) (President)

  2. University of California, San Diego, La Jolla, CA, 92093, USA

    Benjamin W. Zweifach Ph.D. (Professor Emeritus of Bioengineering) (Professor Emeritus of Bioengineering)

  3. University of Heidelberg, D-6900, Heidelberg, Federal Republic of Germany

    Konrad Messmer M.D. (Professor of Experimental Surgery) (Professor of Experimental Surgery)

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Tokyo

About this chapter

Cite this chapter

Kawano, S., Sato, N., Tsuji, S., Kamada, T., Satoh, H., Inatomi, N. (1988). Gastric Microcirculatory Changes Associated with Physicochemical and Ionic Mediators. In: Manabe, H., Zweifach, B.W., Messmer, K. (eds) Microcirculation in Circulatory Disorders. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68078-9_20

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-68078-9_20

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68080-2

  • Online ISBN: 978-4-431-68078-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation