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Gastric Microcirculatory Changes Associated with Physicochemical and Ionic Mediators

  • Sunao Kawano
  • Nobuhiro Sato
  • Shingo Tsuji
  • Takenobu Kamada
  • Hiroshi Satoh
  • Nobuhiro Inatomi

Abstract

The mechanism of stress-induced acute gastric mucosal lesions (AGML) has been investigated for some time. We have reported that in hemorrhagic shock, the decrease of gastric mucosal blood flow, volume, and its oxygenation precedes the gastric ulceration which appears usually after infusion of blood or at the recovery stage in rats and humans. It is believed that the microcirculatory disturbance resulting in hypoxia in the gastric mucosa produced an incipient mucosal state for ulcerogenesis and that in this hydrochloric acid and histamine played an aggressive role. The precise mechanism leading to cell death after ischemia is, however, obscure. In this symposium, we presented a movie film which showed the process of gastric mucosal microcirculatory disturbance and bleeding caused by indomethacin, leukotriene C4 (LTC4), platelet-activating factor (PAF) and HCI and also reported the role of chemical and ionic factors in the repefusion state in the etiology of gastric ulceration.

Keywords

Gastric Mucosa Calcium Antagonist Hemorrhagic Shock Lipid Peroxide Level Mucosal Blood Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • Sunao Kawano
    • 1
  • Nobuhiro Sato
    • 1
  • Shingo Tsuji
    • 1
  • Takenobu Kamada
    • 1
  • Hiroshi Satoh
    • 2
  • Nobuhiro Inatomi
    • 2
  1. 1.First Department of MedicineOsaka University Medical SchoolFukushima-ku, Osaka 553Japan
  2. 2.Central Research DivisionTakeda Chemical Industries LtdYodogawa-ku, Osaka 532Japan

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