Gastric Microvascular Effects of the Pro-ulcerogenic Mediator PAF-Acether

  • Brendan J. R. Whittle
  • Juan V. Esplugues
  • Paul H. Guth


Platelet-activating factor (PAF)-acether is an endogenous phospholipid that can be formed and released by a variety of cell types, including platelets, neutrophils, basophils, macrophages, monocytes and endothelial cells [1]. Its immediate precursor, lyso-PAF, is released from membrane-bound phospholipids by the action of phospholipase A2, the enzyme which also releases arachidonic acid.


Left Gastric Artery Mucosal Blood Flow Gastric Mucosal Blood Flow Corpus Region Acyl Hydrolase 


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Copyright information

© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • Brendan J. R. Whittle
    • 1
  • Juan V. Esplugues
    • 1
  • Paul H. Guth
    • 2
  1. 1.Department of Mediator PharmacologyWellcome Research Laboratories, Langley CourtBeckenham, KentEngland
  2. 2.Center for Ulcer Research and EducationV.A. Wadsworth Hospital CenterLos AngelesUSA

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