Gastric Microvascular Effects of the Pro-ulcerogenic Mediator PAF-Acether

  • Brendan J. R. Whittle
  • Juan V. Esplugues
  • Paul H. Guth


Platelet-activating factor (PAF)-acether is an endogenous phospholipid that can be formed and released by a variety of cell types, including platelets, neutrophils, basophils, macrophages, monocytes and endothelial cells [1]. Its immediate precursor, lyso-PAF, is released from membrane-bound phospholipids by the action of phospholipase A2, the enzyme which also releases arachidonic acid.


Left Gastric Artery Mucosal Blood Flow Gastric Mucosal Blood Flow Corpus Region Acyl Hydrolase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Braquet P, Shen TY, Touqui L, Vargaftig BB (1987) Perspectives in plateletactivating factor research. Pharmacol Rev 39: 97–145PubMedGoogle Scholar
  2. 2.
    Bessin P, Bonnet J, Apffel A, Soulard C, Desgroux L, Pelas I, Benveniste J (1983) Acute circulatory collapse caused by platelet-activating factor (PAF-acether) in dogs. Eur J Pharmacol 86: 403–413PubMedCrossRefGoogle Scholar
  3. 3.
    Rosam AC, Wallace JL, Whittle BJR (1986) Potent ulcerogenic actions of plateletactivating factor on the stomach. Nature 319: 54–56PubMedCrossRefGoogle Scholar
  4. 4.
    Wallace JL, Whittle BJR (1986) Prevention of endotoxin-induced gastrointestinal damage by CV-3988, an antagonist of platelet-activating factor. Eur J Pharmacol 124: 209–210PubMedCrossRefGoogle Scholar
  5. 5.
    Whittle BJR, Boughton-Smith NK, Hutcheson IR, Esplugues JV, Wallace JL (1987) Increased intestinal formation of Paf in endotoxin-induced damage in the rat. Br J Pharmacol 92: 3–4PubMedGoogle Scholar
  6. 6.
    Wallace JL, Whittle BJR (1986) Picomole doses of platelet-activating factor predispose the gastric mucosa to damage by topical irritants. Prostaglandins 31: 989–998PubMedCrossRefGoogle Scholar
  7. 7.
    Esplugues JV, Whittle BJR (1988) Gastric mucosal damage by local intra-arterial administration of Paf in the rat. Br J Pharmacol 93: 222–228PubMedGoogle Scholar
  8. 8.
    Holm-Rutili L, Obrink KJ (1985) Rat gastric microcirculation in vivo. Am J Physiol 248: G741–746PubMedGoogle Scholar
  9. 9.
    Guth PH, Paulson C, Nagata H (1984) Histologic and microcirculatory changes in alcohol-induced gastric lesions in the rat: Effect of prostaglandin cytoprotection. Gastroenterology 87: 1083–1090PubMedGoogle Scholar
  10. 10.
    Whittle BJR, Morishita T, Ohya Y, Leung FW, Guth PH (1986) Microvascular actions of platelet-activating factor on the rat gastric mucosa and submucosa. Am J Physiol 251: G772–778PubMedGoogle Scholar
  11. 11.
    Leung FW, Guth PH, Scremin OU, Golanska EM, Kauffman GL (1984) Regional gastric mucosal blood flow measurements by hydrogen-gas clearance in the anaesthetized rat and rabbit. Gastroenterology 87: 28–36PubMedGoogle Scholar
  12. 12.
    Whittle BJR, Oren-Wolman N, Guth PH (1985) Gastric vasoconstrictor actions of leukotriene C4, PGF, and thromboxane mimetic U-46619 on rat submucosal microcirculation in vivo. Am J Physiol 248: G580–586PubMedGoogle Scholar
  13. 13.
    Doebber JW, Wu WS, Shen TY (1984) Platelet activating factor intravenous infusion in rats stimulates vascular lysosomal hydrolase secretion independent of blood neutrophils. Biochem Biophys Res Comm 125: 980–987PubMedCrossRefGoogle Scholar
  14. 14.
    Wallace JL, Whittle BJR (1986) Effects of inhibitors of arachidonic acid metabolism on PAF-induced gastric mucosal necrosis and haemoconcentration. Br J Pharmacol, 89: 415–422PubMedGoogle Scholar
  15. 15.
    Payne JG Bowen JC (1981) Hypoxia of the canine gastric mucosa caused by Esherichia coli sepsis and prevented by methyl prednisolone therapy. Gastroenterology 80: 84–93PubMedGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • Brendan J. R. Whittle
    • 1
  • Juan V. Esplugues
    • 1
  • Paul H. Guth
    • 2
  1. 1.Department of Mediator PharmacologyWellcome Research Laboratories, Langley CourtBeckenham, KentEngland
  2. 2.Center for Ulcer Research and EducationV.A. Wadsworth Hospital CenterLos AngelesUSA

Personalised recommendations