Chemical Mediators in Ethanol-Induced Increased Jejunal Microvascular Permeability

  • Ivan T. Beck
  • P. K. Dinda
  • Desmond J. Leddin
  • Monica Ray
  • Igor Prokopiw
  • April Boyd


The intraluminal ethanol concentration in the jejunum of man varies between 2% and 9% w/v [1] in the course of moderate drinking. This concentration is 15–100 times higher than that which occurs in the blood (0.08%–0.15%) during mild inebriation. Ethanol is transferred across the epithelial layer of the jejunum by simple diffusion [2]. The capillaries and postcapillary venules of the jejunal villus lie in close proximity to the epithelium. They are separated from the lumen only by a sheet of epithelial cells, the basal lamina of the villous core, and a very thin and loose connective tissue layer. Because of this, ethanol can reach the microvessels in high concentrations and could initiate microvascular damage.


Protein Loss Chemical Mediator Postcapillary Venule Control Segment Perfuse Segment 
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Copyright information

© Springer-Verlag Tokyo 1988

Authors and Affiliations

  • Ivan T. Beck
  • P. K. Dinda
  • Desmond J. Leddin
  • Monica Ray
  • Igor Prokopiw
  • April Boyd
    • 1
  1. 1.The Gastrointestinal Diseases Research Unit, Department of Medicine and Department of Physiology, Hotel Dieu HospitalQueen’s UniversityKingstonCanada

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