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Microcirculation in Circulatory Disorders pp 147–157Cite as

Multiple Organ Failure: Clinical Implications to Macro- and Microcirculation

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Abstract

As result of improved primary resuscitation, a smaller number of all patients suffering from trauma, multiple injuries, and shock succumb within the first critical hours, except those with lethal injury to the vital organ. However, even though tltese patients present with stable hemodynamic conditions for days or weeks after the injury, dysfunction of one or several of their organs becomes apparent and these patients eventually die from late complications of the primary insult, in sepsis and multiple organ failure (MOF) [6, 37]. Baker [4] has demonstrated that age, severity of the injury, shock with arterial pressures below 80 mmHg, and, most importantly, the duration of shock are the crucial factors in the development of MOF. MOF can be the end-stage of shock in both low-flow and high-flow states. As a common denominator of all forms of shock appears the maldistribution of cardiac output, with critical reduction of nutritional blood flow in the vital organs and initiation of shock-specific microcirculatory disturbances [28, 36].

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Author information

Authors and Affiliations

  1. Department of Experimental Surgery, University of Heidelberg, Im Neuenheimer Feld 347, 6900, Heidelberg 1, Federal Republic of Germany

    Konrad Messmer & Uwe Kreimeieri

  2. Department of Anatomy, Technical University of Munich, Biedersteiner str. 29, 8000, Munich, Federal Republic of Germany

    Frithjof Hammersen

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  1. Konrad Messmer
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  2. Uwe Kreimeieri
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  3. Frithjof Hammersen
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Editor information

Editors and Affiliations

  1. National Cardiovascular Center of Japan, Suita, Osaka, 565, Japan

    Hisao Manabe M.D. (President) (President)

  2. University of California, San Diego, La Jolla, CA, 92093, USA

    Benjamin W. Zweifach Ph.D. (Professor Emeritus of Bioengineering) (Professor Emeritus of Bioengineering)

  3. University of Heidelberg, D-6900, Heidelberg, Federal Republic of Germany

    Konrad Messmer M.D. (Professor of Experimental Surgery) (Professor of Experimental Surgery)

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© 1988 Springer-Verlag Tokyo

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Messmer, K., Kreimeieri, U., Hammersen, F. (1988). Multiple Organ Failure: Clinical Implications to Macro- and Microcirculation. In: Manabe, H., Zweifach, B.W., Messmer, K. (eds) Microcirculation in Circulatory Disorders. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68078-9_16

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  • DOI: https://doi.org/10.1007/978-4-431-68078-9_16

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68080-2

  • Online ISBN: 978-4-431-68078-9

  • eBook Packages: Springer Book Archive

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