Organ Failure and Disseminated Intravascular Coagulation
Disseminated intravascular coagulation (DIC) involves the formation of fibrin from fibrinogen. This results in two important effects: (a) The onset of a clotting defect due primarily to the using up of clotting factors faster than they can be manufactured. (b) The precipitation of fibrin fibers primarily on the most available surface, that of red cells (Fig. 1). This results in the formation of red cell conglomerates, which occlude the microcirculation. It is this second effect which is our present concern.
KeywordsLactic Acid Septic Shock Organ Failure Disseminate Intravascular Coagulation Hemorrhagic Shock
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