The Effect of Multiple Organ Failure on the Regulation of the Circulation with Special Reference to the Microcirculation
The evolution of shock research in the latter half of this century has been one of investigating more and more complex experimental models as the mechanisms behind the less complex clinical situations become better understood. Such an understanding has usually led quite quickly to clinical application of the newly gained information. Thus, pure hemorrhagic shock models gave way to models of combined traumatic-hemorrhagic shock, and these have in turn given way to models of sepsis-endotoxin shock. It is also true that the clinical situations are never as “pure” as the experimental models, so that while trauma and sepsis can be separated in the laboratory they are often combined in the clinic. Failure to recover from these pathological conditions in a relatively rapid time frame leads to organ failure and at the end of the line is the specter multiple organ failure.
KeywordsMyocardial Blood Flow Multiple Organ Failure Postcapillary Venule Sympathoadrenal System Myocardial Blood Volume
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- 4.Lewis DH (1987) Do the sympathetics play a role in the maintenance of microvascular hematocrit? Fed Proc 46: 1532Google Scholar
- 6.Lewis DH, Schmid-Schönbein H (1981) Rheology and vasomotion: A validation of hemodilution as a rational therapeutic manuever. In: Schmid-Schönbein H, Messmer K, Rieger H (eds) Hemodilution and flow improvement. Bibliohca Haemat nr. 47. Karger, Basel, pp 122–126Google Scholar
- 8.Engler RL, Schmid-Schönbein GV, Pavelec RS (1983) Leukocyte capillary plugging in myocardial ischemia and reperfusion in the dog. Am J Pathol 111: 96–111Google Scholar
- 14.Lewis DH, Gidlöf A, Behm KE, Bengtsson M-B, Menschik A (1987) White cells in shock ischemia. In: Schlag G, Redl H (eds) First Vienna shock forum: A. Pathophysiological role of mediators and mediator inhibitors in shock. Liss, New York, pp 63–74Google Scholar
- 15.Gidlöf A, Lewis DH, Hammersen F (1988) The effect of prolonged total ischemia on the ultrastructure of human skeletal muscle capillaries. A morphometric analysis. Int J Microcirc: Clin Exp 7: 67–86Google Scholar