A hypothesis of a common origin of peptide/amine producing endocrine cells was proposed by Pearse (1966a, b, 1968). He conceived that all amine precursor uptake and decarboxylation (APUD) cells might be derived from the neural crest. By examining dopa-provoked formaldehyde-induced fluorescence (FIF) in mouse embryos, Pearse and Polak (1971a) reported that thyroid parafollicular cells are derived from the neural crest since the neural crest cells, cells migrating from there, and the cells which have settled in the thyroid were all FIF positive. The same conclusion was reached by Pearse and Polak (1971a, b) concerning the endocrine cells in the pancreas, gut, and respiratory tract.
KeywordsNeural Tube Neural Crest Endocrine Cell Neural Crest Cell Gustatory Cell
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