The mast cell is a unicellular endocrine/paracrine element dispersed in the connective tissue. Since it is a typical receptosecretory cell producing monoamines it would seem reasonable to include this cell among the paraneurons. As discussed in the general section (p. 9), however, the mast cell also shows some cell-biological and ontogenetic features that deviate from those of paraneurons, and it thus becomes debatable whether it should be classed as a paraneuron. In this chapter, the paraneuronal features of mast cells will be presented. Experimental data concerning the secretory mechanisms in an isolated mast cell will be included as a model for paraneuron study.
KeywordsMast Cell Secretory Granule Histamine Release Phosphatidyl Inositol Mast Cell Granule
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