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Actions of Calcium Antagonists on Smooth Muscle Cells of Vascular Tissues

Current Knowledge on Actions of Ca Antagonists

  • Chapter
Essential Hypertension

Summary

The actions of Ca antagonists, organic compounds which prevent the influx of Ca, were studied in various regions of vascular beds excised from several species using the micro-electrode and whole-cell voltage clamp methods. In relation to the actions of Ca antagonists on the membrane, the effects of these drugs on mechanical responses evoked by the Ca spike and depolarizations induced by high K or agonists were studied using the isometric tension recording method. In vascular smooth muscle, most Ca antagonists inhibited the voltage-dependent Ca channel to a greater extent than the receptor-operated Ca channel. However, some Ca antagonists inhibited not only the influx of Ca but also the Ca mobilization in smooth muscle cells. Since individual Ca antagonists possess different features on inhibition of the smooth muscle activity, we tentatively classified the Ca antagonists from their actions on the Ca-dependent and receptor-operated Ca channels, sarcoplasmic reticulum, and contractile proteins. The inhibitory actions of Ca antagonists on cardiac muscle are briefly discussed in comparison to those on vascular smooth muscle.

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, Kyushu University, Fukuoka, 812, Japan

    Y. Ohya, K. Terada, S. Satoh, T. Fujiwara, T. Nagao, K. Komori, M. Nozaki & H. Kuriyama

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  1. Y. Ohya
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  2. K. Terada
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  4. T. Fujiwara
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  1. 2nd Department of Internal Medicine, Nagoya City University Medical School, Mizuho-ku, Nagoya, 467, Japan

    Kyuzo Aoki

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Ohya, Y. et al. (1986). Actions of Calcium Antagonists on Smooth Muscle Cells of Vascular Tissues. In: Aoki, K. (eds) Essential Hypertension. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68048-2_7

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  • DOI: https://doi.org/10.1007/978-4-431-68048-2_7

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