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Altered Vascular Calcium Metabolism As a Possible Cause of Increased Blood Pressure in Essential Hypertension

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Book cover Essential Hypertension

Summary

In human essential hypertension, there is some limited evidence for vascular EC coupling abnormalities, and abnormalities are also found in the SHR. There is little information from human studies as to whether such abnormalities play a role in the development of hypertension, but from rat studies the available evidence does not support a direct connection between EC coupling abnormalities and increased blood pressure, although the possibility cannot be excluded that the increased sensitivity is a substrate upon which other factors may act. Further work is required, particularly using human isolated vascular preparations, to delineate more precisely the role of vascular abnormalities in the pathogenesis of essential hypertension.

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Authors and Affiliations

  1. Biophysics Institute, Aarhus University, 8000, Aarhus C, Denmark

    M. J. Mulvany

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  1. 2nd Department of Internal Medicine, Nagoya City University Medical School, Mizuho-ku, Nagoya, 467, Japan

    Kyuzo Aoki

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© 1986 Springer-Verlag Tokyo

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Mulvany, M.J. (1986). Altered Vascular Calcium Metabolism As a Possible Cause of Increased Blood Pressure in Essential Hypertension. In: Aoki, K. (eds) Essential Hypertension. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68048-2_5

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  • DOI: https://doi.org/10.1007/978-4-431-68048-2_5

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68050-5

  • Online ISBN: 978-4-431-68048-2

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