Summary
The calcium antagonist drug verapamil was compared in double-blind, double-dummy crossover studies with two beta-adrenoceptor blocking drugs, pindolol and labetalol. All were equally effective as antihypertensive drugs in patients with mild to moderate hypertension. Verapamil caused a fall in blood pressure by reducing total peripheral resistance; since cardiac output rose slightly as judged by echocardiographic studies, verapamil had no adverse effects on airways resistance in patients with obstructive airways disease. The favourable haemodynamic effects and absence of serious side effects suggest that verapamil may represent an important advance in the treatment of mild to moderate hypertension.
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© 1986 Springer-Verlag Tokyo
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Doyle, A.E. (1986). Comparative Efficacy of Calcium Antagonists and Beta Blockers in Essential Hypertension. In: Aoki, K. (eds) Essential Hypertension. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68048-2_20
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DOI: https://doi.org/10.1007/978-4-431-68048-2_20
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68050-5
Online ISBN: 978-4-431-68048-2
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