Integrity of Myocardial Fiber Structure Maintained by Fiber Load Induced Local Growth
In a mathematical simulation of left ventricular wall mechanics, it is hypothesized that the process of left ventricular hypertrophy is controlled by the feedback signals: fiber stress, end-diastolic sarcomere length, and sarcomere shortening during ejection. In this simulation, a stable final solution is found for the transmural course of fiber orientation, in which cardiac muscle is loaded homogeneously within ± 2%. The solution is self-correcting for deviations in the anatomical structure. The transmural course of fiber orientation thus found is not significantly different from anatomical findings reported in many species. Thus, according to the simulation, the global, complicated cardiac structure can be maintained by control signals on the cellular level.
KeywordsFiber Orientation Fiber Stress Left Ventricular Pressure Aortic Valve Stenosis Myocardial Fiber
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