Regional Wall Motion in the Ischemic Heart

  • Hitonobu Tomoike
  • Yoshitoshi Urabe
  • Shunichi Kaseda
  • Motoomi Nakamura


Determinants of regional wall motion were examined during regional coronary hypoperfusion, changes in regional coronary contractile state, and coronary occlusions. The lowest coronary perfusion pressure for maintaining the regional shortening increased when the level of ventricular pressure was elevated by pulmonary artery constriction, which suggests the importance of afterload as one of determinants of regional shortening. The relationship between regional segment length and ventricular pressure was visualized as a loop, and the end-systolic pressure-length relation was determined during progressive declines of preload following occlusion of the inferior caval vein in homogeneously or heterogeneously contracting heart in open-chest dogs. Although the changes in slope of the end-systolic pressure-length relation theoretically represent the elastance of systolic myocardium, the x-axis intercept, but not the slope of the end-systolic pressure-length relation, altered, correlating with changes in contractile state. The level of the x-axis intercept of the regional myocardium, rendered ischemic, increased following an extension of infarct size, which suggests the stretch of ischemic myocardium from the surrounding intact myocardium. Analysis of regional wall motion on the trajectories of the pressure-length (wall thickness) relation facilitates understanding of regional wall motion unique to muscle properties.


Coronary Occlusion Regional Wall Motion Coronary Perfusion Pressure Contractile State Left Circumflex Coronary Artery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Tennant R, Wiggers CJ (1935) The effect of coronary occlusion of myocardial contraction. Am J Physiol 112:351–361Google Scholar
  2. 2.
    Tyberg JV, Parmley WW, Sonnenblick EH (1969) in vitro studies of myocardial asynchrony and regional hypoxia. Circ Res 25: 569–579PubMedGoogle Scholar
  3. 3.
    Kaseda S, Tomoike H, Ogata I, Nakamura M (1984) End-systolic pressure-length relations during changes in regional contractile state. Am J Physiol 247 (Heart Circ Physiol 16): H768–H774PubMedGoogle Scholar
  4. 4.
    Gallagher KP, Osakada G, Hess OM, Koziol JA, Kemper WS, Ross J Jr (1982) Subepicardial segment function during coronary stenosis and the role of myocardial fiber orientation. Circ Res 50: 352–359PubMedGoogle Scholar
  5. 5.
    Lew WYW, Le Winter MM (1986) Regional comparison of midwall segmental and area shortening in the canine left ventricle. Circ Res 58: 678–691PubMedGoogle Scholar
  6. 6.
    Tomoike H (1982) Analysis of in situ heart mechanics. Jpn Circ J 46: 1108–1111PubMedCrossRefGoogle Scholar
  7. 7.
    Tomoike H, Franklin D, McKown D, Kemper M, Guberek M, Ross J Jr (1978) Regional myocardial dysfunction and hemodynamic abnormalities during strenuous exercise in dogs with limited coronary flow. Circ Res 42: 487–496PubMedGoogle Scholar
  8. 8.
    Tomoike H, Franklin D, Ross J Jr (1978) Detection of myocardial ischemia by regional dysfunction during and after rapid pacing in conscious dogs. Circulation 58: 48–56PubMedGoogle Scholar
  9. 9.
    Sonnenblick EH, Braunwald E, Williams JF Jr, Glick G (1965) Effects of exercise on myocardial force-velocity relations in intact anesthetized man: Relative roles of changes in heart rate, sympathetic activity, and ventricular dimensions. J Clin Invest 44: 2051–2062PubMedCrossRefGoogle Scholar
  10. 10.
    Pfeffer MA, Pfeffer JM, Fishbein MC, Fletcher PJ, Spadaro J, Kloner JA, Braunwald E (1979) Myocardial infarct size and ventricular function in rats. Circ Res 44: 503–512PubMedGoogle Scholar
  11. 11.
    Urabe Y, Tomoike H, Ohzono K, Koyanagi S, Nakamura M (1985) Role of afterload in determining regional right ventricular performance during coronary underperfusion in dogs. Circ Res 57: 96–104PubMedGoogle Scholar
  12. 12.
    Suga H, Sagawa K, Shoukas AA (1973) Load independence of the instantaneous pressure-volume ratio of the canine left ventricle and effects of epinephrine and heart rate on the ratio. Circ Res 32: 314–322PubMedGoogle Scholar
  13. 13.
    Sagawa K (1978) The ventricular pressure-volume diagram revisited. Circ Res 43: 677–687PubMedGoogle Scholar
  14. 14.
    Weber KT, Janicki JS, Hefner LL (1976) Left ventricular force-length relations of iso-volumic and ejecting contractions. Am J Physiol 231: 337–343PubMedGoogle Scholar
  15. 15.
    Sagawa K, Sunagawa K, Maughan WL (1985) Ventricular end-systolic pressure-volume relations. In: Levine HJ, Gaasch WH (eds) The ventricle: basic and clinical aspects. Martinus Nijhoff, Boston, pp 79–103Google Scholar
  16. 16.
    Grossman W, Braunwald E, Mann T, McLaurin LP, Green LH (1977) Contractile state of the left ventricle in man as evaluated from end-systolic pressure-volume relations. Circulation 56: 845–852PubMedGoogle Scholar
  17. 17.
    Borow KM, Neumann A, Wynne T (1982) Selectivity of end-systolic pressure-dimension and pressure-volume relations to the inotropic state in humans. Circulation 65:988–996PubMedCrossRefGoogle Scholar
  18. 18.
    Sodums MT, Badke FR, Starling MR, Little WC, O’Rourke RA (1984) Evaluation of left ventricular contractile performance utilizing end-systolic pressure-volume relationships in conscious dogs. Circ Res 54: 731–739PubMedGoogle Scholar
  19. 19.
    Sagawa K, Suga H, Shoukas AA, Bakalar KM (1979) End-systolic pressure-volume ratio: A new index of contractility. Am J Cardiol 40: 748–753CrossRefGoogle Scholar
  20. 20.
    Miller WP, Liedke AJ, Nellis SH (1984) Regional end-systolic pressure-length relationships using a volume loading technique in the intact pig heart. Circ Res 55: 326–335PubMedGoogle Scholar
  21. 21.
    Way B, Victory J, LeWinter MM, Lew WY, Doyle R, Foëx P, Ryder WA, Jones LA (1986) Hysteresis of left ventricular end ejection pressure-dimension relations after acute pressure loading in the intact canine heart. Cardiovasc Res 20: 490–497PubMedCrossRefGoogle Scholar
  22. 22.
    Osakada G, Hess OM, Gallagher KP, Kemper WS, Ross J Jr (1983) End-systolic dimension-wall thickness relations during myocardial ischemia in conscious dogs. A new approach for defining regional function. Am J Cardiol 51: 1750–1758PubMedCrossRefGoogle Scholar
  23. 23.
    Kaseda S, Tomoike H, Ogata I, Nakamura M (1985) End-systolic pressure-volume, pressure-length, and stress-strain relations in canine hearts. Am J Physiol 249 (Heart Circ Physiol 18): H648–H654PubMedGoogle Scholar
  24. 24.
    Kaseda S, Tomoike H, Ogata I, Nakamura M (1982) Regional left ventricular end-systolic pressure-length relation in ischemic area shifts rightward with extension of ischemia. Circulation (Suppl II) 66: II-255Google Scholar
  25. 25.
    Kumada T, Karliner JS, Pouleur H, Gallagher KP, Shirato K, Ross J Jr (1979) Effects of coronary occlusion on early ventricular events in conscious dogs. Am J Physiol 237: H542–H549PubMedGoogle Scholar
  26. 26.
    Sasayama S, Franklin D, Ross J Jr, Kemper WS, McKown D (1976) Dynamic changes in left ventricular wall thickness and their use in analyzing cardiac function in the conscious dog. Am J Cardiol 38: 870–879PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1989

Authors and Affiliations

  • Hitonobu Tomoike
  • Yoshitoshi Urabe
  • Shunichi Kaseda
  • Motoomi Nakamura
    • 1
  1. 1.Research Institute of Angiocardiology and Cardiovascular Clinic, Faculty of MedicineKyushu UniversityFukuokaJapan

Personalised recommendations