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Cardiac Mechanics and Function in the Normal and Diseased Heart pp 189–197Cite as

Ventricular Pressure-Volume Relations Demonstrate Positive Inotropic Effect of Increased Arterial Impedance

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Summary

The influence of different types of loading intervention on the end-systolic pressure-volume relation (ESPVR) of the left ventricle (LV) in situ was investigated in anesthetized open-chest dogs. LV volume was measured by conductance catheter. Two loading interventions were applied: a pressure intervention (INp) by gradually occluding the descending aorta, and a volume intervention (INv) by rapidly infusing 180 ml blood intathe vena cava. The P-V loops during an intervention always showed a linear ESPVR, the slope of which, Ees, was calculated. Results from 16 dogs show that Ees(INp) was always larger (1.37 ± 0.45 kPa/ml) than Ees(INv) (0.73 ± 0.32 kPa/ml) (P<.001). This difference was enhanced by beta-blockade through metoprolol. The same phenomenon was found for the slope (SdPV) of the relation between dP/dtmax and EDV: SdPV(INp) = 45.17 ± 22.63 kPa/ml per s and SdPV(INv) = 20.55 ± 11.13 kPa/ml per s (P <.001).

Since INv increases stroke volume while INp decreases it, the results can be explained in part by shortening deactivation. However, the similar behavior of SdPV as compared to Ees suggests that INp leads to an increased inotropic state with respect to INv. We speculate that an intrinsic myocardial mechanism related to changes in calcium turnover forms the basis of this phenomenon.

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Authors and Affiliations

  1. Laboratory of Clinical Physiology, Department of Cardiology, Leiden University Hospital, Leiden, The Netherlands

    Enno T. van der Velde

Authors
  1. Jan Baan
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  2. Enno T. van der Velde
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Editor information

Editors and Affiliations

  1. The First Department of Medicine, Osaka University School of Medicine, Fukushima-ku, Osaka, 553, Japan

    Masatsugu Hori

  2. Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Suita, Osaka, 565, Japan

    Hiroyuki Suga

  3. Laboratory of Clinical Physiology, Department of Cardiology, Leiden University Hospital, Leiden, The Netherlands

    Jan Baan

  4. Department of Cardiothoracic Surgery and Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University, The Bronx, NY, 10461, USA

    Edward L. Yellin

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© 1989 Springer-Verlag Tokyo

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Baan, J., van der Velde, E.T. (1989). Ventricular Pressure-Volume Relations Demonstrate Positive Inotropic Effect of Increased Arterial Impedance. In: Hori, M., Suga, H., Baan, J., Yellin, E.L. (eds) Cardiac Mechanics and Function in the Normal and Diseased Heart. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67957-8_18

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  • DOI: https://doi.org/10.1007/978-4-431-67957-8_18

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68020-8

  • Online ISBN: 978-4-431-67957-8

  • eBook Packages: Springer Book Archive

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