Pressure-Volume Relation of the Left Atrium in Man
The reservoir function of the left atrium is important in producing an appropriate driving pressure and in providing an appropriate amount of blood for the following ventricular rapid filling.
To quantify this reservoir function in terms of the compliance, we simultaneously measured left atrial volume with biplane cineangiography and left atrial pressure, and reconstructed the pressure-volume relation in 10 patients with normal cardiac function. We tested the hypothesis that the pressure-volume relation of the left atrium during the ascending limb of the v-loop is largely a passive state. For this purpose, we observed whether the pressure-volume relation could be described as an exponential function (p = b·eaV: p, pressure; a and b, constants; V, Volume) which is widely accepted to describe the passive filling characteristics of the left ventricle in diastole.
The correlation coefficient of the regression equation was 0.96 ± 0.04 (mean ± SD), indicating that the strength of the relationship is great between the pressure and volume and that the slope of this regression line is gentle at low pressure and is steeper at high pressure. The left atrial compliance at the pressure of the peak v-wave (13.5 ± 3.6 mmHg) was 1.03 ± 0.26 ml·mmHg-1·m-.
We conclude that the pressure-volume relation is curvilinear during the ascending limb of the v-loop and that the reservoir function of the left atrium appears to be relatively small.
KeywordsMitral Valve Left Atrium Left Atrial Volume Left Atrial Pressure Atrial Contraction
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