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Myocardial Energetics of Hypertrophied Heart of Spontaneously Hypertensive Rat and Stroke-Prone Spontaneously Hypertensive Rat

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Recent Progress in Failing Heart Syndrome

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Summary

Left ventricular mechanical efficiency was examined in isolated working hearts of 7-month-old spontaneous hypertensive rats (SHR), stroke prone SHR (SHR-SP), and control Wistar-Kyoto rats (WKY). The heart was perfused with Krebs solution at 37°C and at three different afterloads (70mmHg for WKY, 90mmHg for SHR and 110mmHg for SHR-SP) in order to maintain constant coronary perfusion per gram of the myocardium. Oxygen pressure was measured at the left atrium and the right ventricle which received coronary sinus flow. Mechanical efficiency was calculated as minute stroke work (Joules) divided by energy production by O2 (Joules). Energy utilization was impaired in SHR and SHR-SP (WKY, 27 ± 6.9%; and SHR, 14 ± 3.8%, P < 0.01; SHR-SP, 13 ± 6.7%, P < 0.01, in comparison with control value) when the myocardial perfusion showed no significant difference. Therefore, the energy utilization in SHR and SHR-SP was impaired even when the coronary perfusion was sufficient. Our findings may contradict demonstrations of a shift in heavy chain myosin isozymes in hypertrophied small animal hearts, but may suggest that more drastic changes in the myocardium, which are disadvantageous to the myothermal economy, are present in the hypertrophied heart.

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References

  1. Gunning JF, Coleman HN (1973) Myocardial oxygen consumption during experimental hypertrophy and congestive heart failure. J Moll Cell Cardiol 5:25–38.

    Article  CAS  Google Scholar 

  2. Cooper G IV, Satava RM Jr, Harrison CE, Coleman HN III (1973) Mechanism for the abnormal energetics of pressure-induced hypertrophy of cat myocardium. Circ Res 33:213–223.

    PubMed  Google Scholar 

  3. Alpert NR, Mulieri LA (1982) Increased myothermal economy of isometric force generation in compensated cardiac hypertrophy induced by pulmonary artery constriction in the rabbit. A characterization of heat liberation in normal and hypertrophied right ventricular papillary muscles. Circ Res 50:491–500.

    CAS  Google Scholar 

  4. Lompre AM, Schwartz K, d’Albis A, Lacombe G, Thiem NV, Swynghedauw B (1979) Myosin isozyme redistribution in chronic heart overload. Nature 282: 105–107.

    Article  PubMed  CAS  Google Scholar 

  5. Spann JF Jr, Buccino RA, Sonnenblick EH, Braunwald E (1967) Contractile state of cardiac muscle obtained from cats with experimentally produced ventricular hypertrophy and heart failure. Circ Res 21:341–354.

    PubMed  Google Scholar 

  6. Bing OHL, Matsushita S, Fanburg BL, Levine HJ (1971) Mechanical properties of rat cardiac muscle during experimental hypertrophy. Circ Res 28:234–245.

    PubMed  CAS  Google Scholar 

  7. Sasayama S, Ross J Jr, Franklin D, Bloor CM, Bishop S, Dilley RB (1976) Adaptation of the left ventricle to chronic pressure overload. Circ Res 38:172–178.

    PubMed  CAS  Google Scholar 

  8. Gaasch WH, Zile MR, Hoshino PK, Apstein CS, Blaustein AS (1989) Stressshortening relations and myocardial blood flow in compensated and failing canine hearts with pressure-overloaded hypertrophy. Circulation 79:872–883.

    Article  PubMed  CAS  Google Scholar 

  9. Morioka S, Simon G (1982) Echocardiographic evidence for early left ventricular hypertrophy in dogs with renal hypertension. Am J Cardiol 49:1891–1898.

    Article  Google Scholar 

  10. Okamoto K, Aoki K (1963) Development of a strain of spontaneously hypertensive rats. Jpn Circ J 27: 282–293.

    Article  PubMed  CAS  Google Scholar 

  11. Pfeffer MA, Pfeffer JM, Frohlich ED (1976) Pumping ability of the hypertrophying left ventricle of the spontaneously hypertensive rat. Circ Res 38:423–429.

    PubMed  CAS  Google Scholar 

  12. Bing OHL, Sen S, Conrad CH, Brooks WW (1984) Myocardial function structure and collagen in the spontaneously hypertensive rat: progression from compensated hypertrophy to haemodynamic impairment. Eur Heart J 5(Suppl F):43–52.

    PubMed  Google Scholar 

  13. Nakamura Y, Bing OHL, Wiegner AW, Konishi T, Apstein CS, Pfeffer MA, Kawai C (1986) Effects of hypertrophy and allylamine-induced fibrosis on mechanical properties of isolated rat heart muscles with references to the pumping function of the intact heart in the same models. Jpn Circ J 50:998–1006.

    Article  PubMed  CAS  Google Scholar 

  14. Saito N, Matsunaga M, Hara A, Yamamota J, Yamori Y, Mukaino S, Ogino K, Kawai C (1975) Hypertensive vascular lesions and renin or lysosomal enzymes in rats. Jpn Circ J 39:551–558.

    Article  PubMed  CAS  Google Scholar 

  15. Neely JR, Rovetto MJ, Whitmer JT, Morgan ME (1973) Effects of ischemia on function and metabolism of the isolated working rat heart. Am J Physiol 225: 651–658.

    PubMed  CAS  Google Scholar 

  16. Konishi T, Nakamura Y, Konishi T, Kawai C (1984) Accentuated negative inotropism of verapamil after ischemic intervention in isolated working rat heart. Cardiovasc Res 18:639–644.

    Article  PubMed  CAS  Google Scholar 

  17. Linzbach AJ (1960) Heart failure from the point of view of quantitative anatomy. Am J Cardiol 5:370–382.

    Article  PubMed  CAS  Google Scholar 

  18. Henquell L, Odoroff CL, Honig CR (1976) Intercapillary distance and capillary reserve in hypertrophied rat hearts beating in situ. Circ Res 41:400–408.

    Google Scholar 

  19. Tomanek RJ, Searls JC, Lachenbruch PA (1982) Quantitative changes in the capillary bed during developing, peak, and stabilized cardiac hypertrophy in the spontaneously hypertensive rat. Circ Res 51:295–304.

    PubMed  CAS  Google Scholar 

  20. Holubarsch Ch, Goulette RP, Litten RZ, Martin BJ, Mulieri LA, Alpert NR (1985) The economy of isometric force development, myosin isoenzyme pattern and myofibrillar ATPase activity in normal and hypothyroid rat myocardium. Circ Res 56:78–86.

    PubMed  CAS  Google Scholar 

  21. Sordahl LA, McCollum WB, Wood WG, Schwartz A (1973) Mitochondria and sarcoplasmic reticulum function in cardiac hypertrophy and failure. Am J Physiol 224:497–502.

    PubMed  CAS  Google Scholar 

  22. Ito Y, Suko J, Chidsey CA (1974) Intracellular calcium and myocardial con¬tractility. V. Calcium uptake of sarcoplasmic reticulum fractions in hypertrophied and failing rabbit hearts. J Mol Cell Cardiol 6:237–247.

    CAS  Google Scholar 

  23. Komuro I, Kurabayashi M, Shibazaki Y, Takaku F, Yazaki Y (1989) Molecular cloning and characterization of a Ca2+ + Mg2+-dependent adenosine triphophatase from rat cardiac sarcoplasmic reticulum. Regulation of its expression by pressure overload and developmental stage. J Clin Invest 83:1102–1108.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan

    Keijiro Kusunoki, Takashi Konishi & Chuichi Kawai

  2. First Department of Medicine, Shiga University of Medical Science, Shiga, 520-21, Japan

    Yasuyuki Nakamura

  3. College of Medical Technology, Kyoto University, Kyoto, Japan

    Masato Matsunaga

Authors
  1. Keijiro Kusunoki
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  2. Yasuyuki Nakamura
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  3. Takashi Konishi
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  4. Masato Matsunaga
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  5. Chuichi Kawai
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Editor information

Editors and Affiliations

  1. The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-01, Toyama, Japan

    Shigetake Sasayama M.D. (Professor of Medicine) (Professor of Medicine)

  2. Okayama University Medical School, 2-5-1, Shikata-cho, 700, Okayama, Japan

    Hiroyuki Suga M.D., D.M. SC. (Professor of Physiology) (Professor of Physiology)

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© 1991 Springer-Verlag Tokyo

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Kusunoki, K., Nakamura, Y., Konishi, T., Matsunaga, M., Kawai, C. (1991). Myocardial Energetics of Hypertrophied Heart of Spontaneously Hypertensive Rat and Stroke-Prone Spontaneously Hypertensive Rat. In: Sasayama, S., Suga, H. (eds) Recent Progress in Failing Heart Syndrome. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67955-4_6

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  • DOI: https://doi.org/10.1007/978-4-431-67955-4_6

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68019-2

  • Online ISBN: 978-4-431-67955-4

  • eBook Packages: Springer Book Archive

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