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Systematic Detection of DNA Alteration in Cancer Tissue

  • Yasushi Okazaki
  • Tomoya Ohsumi
  • Hisato Okuizumi
  • William A. Held
  • Yoshihide Hayashizaki
Part of the Springer Lab Manuals book series (SLM)

Abstract

Tumorigenesis is a multistep process involving both epigenetic and genetic alterations [1,2]. The identification of gain of function mutations in proto-oncogenes and loss of function mutations in tumor suppressor genes has provided a rationale for understanding tumorigenesis. However, the mutation of a single protooncogene or tumor suppressor gene is usually not sufficient to cause neoplastic growth. Tumor progression depends on secondary events which arise during cell proliferation. The genetic targets for these secondary events would be expected to depend on the initiating event as well as developmental and tissue-specific factors regulating cell proliferation. Additional steps involving angiogenesis, invasive growth, and metastasis generate more serious life-threatening malignant disease [3]. Although the “cast of characters” involved in these processes is large and growing, our understanding of the process is complicated by the large number of genes involved, developmental and tissue-specific differences in growth regulation, and the stochastic nature of the process.

Keywords

Spot Intensity Simple Sequence Length Polymorphism Restriction Landmark Genomic Scanning Simple Sequence Length Polymorphism Restriction Landmark Genomic Scanning Profile 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 1997

Authors and Affiliations

  • Yasushi Okazaki
  • Tomoya Ohsumi
  • Hisato Okuizumi
  • William A. Held
  • Yoshihide Hayashizaki

There are no affiliations available

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