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Regulation of Inducible Nitric Oxide Synthase in the Retina

  • Olivier Goureau
  • Violaine Faure
  • Yvonne De Kozak
  • Francine Behar-Cohen
  • Pablo Dighiero
  • Yves Courtois

Abstract

Nitric oxide (NO) is known to be synthesized enzymatically in a tightly regulated manner by a number of tissues and cell types. The NO produced by cells serves a wide variety of functions in such cells as vascular endothelia, immune cells, neurons and glia, hepatocytes, and smooth muscle cells (for review, Bredt and Snyder 1994; Knowles and Moncada 1994; Nathan and Xie 1994). The functions of NO are diverse, having actions on vascular tone, neurotransmission (Bredt and Snyder 1994), immune cytotoxicity (Nüssler and Billiar 1993), and others.

Keywords

Nitric Oxide Retinal Pigment Epithelial Cell Retinal Pigment Epithelial Retinal Pigment Epithelial Cell Nitrite Release 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Beckman JS, Crow JP (1993) Pathological implications of nitric oxide, superoxide and peroxynitrite formation. Biochem Soc Transact 21:330–334Google Scholar
  2. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA (1990) Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87:1620–1624PubMedCrossRefGoogle Scholar
  3. Becquet F, Courtois Y, Goureau O (1994) Nitric oxide decreases in vitro phagocytosis of photoreceptor outer segments by bovine retinal pigmented epithelial cells. J Cell Physiol 159:256–262PubMedCrossRefGoogle Scholar
  4. Behar-Cohen F, Goureau O, D’Hermies F, Courtois Y (1996a) Decreased intraocular pressure induced by nitric oxide donors is correlated to nitrite production in the rabbit eye. Invest Ophthalmol Vis Sci 37:1711–1715PubMedGoogle Scholar
  5. Behar-Cohen F, Heydolph S, Faure V, Droy-Lefaix M, Courtois Y, Goureau O (1996b) Peroxynitrite cytotoxicity on bovine retinal pigmented epithelial cells in culture. Biochem Biophys Res Commun 226:842–859PubMedCrossRefGoogle Scholar
  6. Bredt DS, Snyder SH (1994) Nitric oxide: a physiologic messenger molecule. Annu Rev Biochem 63:175–195PubMedCrossRefGoogle Scholar
  7. Dighiero P, Reux I, Hauw JJ, Fillet AM, Courtois Y, Goureau O (1994) Expression of inducible nitric oxide synthase in cytomegalovirus-infected glial cells of retinas from AIDS patients. Neurosci Lett 166:31–34PubMedCrossRefGoogle Scholar
  8. Goldstein IM, Ostwald P, Roth S (1996) Nitric oxide: a review of its role in retinal function and disease. Vis Res 36:2979–2994PubMedCrossRefGoogle Scholar
  9. Goureau O, Courtois Y (1996) Nitric oxide in the retina: a double face mediator. Med Sci 12:593–598Google Scholar
  10. Goureau O, Lepoivre M, Courtois Y (1992) Lipopolysaccharide and cytokines induce a macrophage-type of nitric oxide synthase in bovine retinal pigmented epithelial cells. Biochem Biophys Res Commun 186:854–859PubMedCrossRefGoogle Scholar
  11. Goureau O, Lepoivre M, Becquet F, Courtois Y (1993) Differential regulation of inducible nitric oxide synthase by basic fibroblast growth factors and transforming growth factor β in bovine retinal pigmented epithelial cells: inverse correlation with cellular proliferation Proc Natl Acad Sci USA 90:4276–4280PubMedCrossRefGoogle Scholar
  12. Goureau O, Hicks D, Courtois Y (1994a) Human retinal pigmented epithelial cells produce nitric oxide in response to cytokines. Biochem Biophys Res Commun 198:120–126PubMedCrossRefGoogle Scholar
  13. Goureau O, Hicks D, Courtois Y, de Kozak Y (1994b) Induction and regulation of nitric oxide synthase in retinal müller glial cells. J Neurochem 63:310–317PubMedCrossRefGoogle Scholar
  14. Goureau O, Faure V, Courtois Y (1995a) Fibroblast growth factors decrease inducible nitric oxide synthase mRNA accumulation in bovine retinal pigmented epithelial cells. Eur J Biochem 230:1046–1052PubMedCrossRefGoogle Scholar
  15. Goureau O, Bellot J, Thillaye B, Courtois Y, de Kozak Y (1995b) Increased nitric oxide production in endotoxin-induced uveitis. J Immunol 154:6518–6523PubMedGoogle Scholar
  16. Jacquemin E, de Kozak Y, Thillaye B, Courtois Y, Goureau O (1996) Expression of inducible nitric oxide synthase in the eye from endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci 37:1187–1196PubMedGoogle Scholar
  17. Knowles RG, Moncada S (1994) Nitric oxide synthases in mammals. Biochem J 298: 249–258PubMedGoogle Scholar
  18. Liversidge J, Grabowski P, Ralston S, Benjamin N, Forrester JV (1994) Rat retinal pigment epithelial cells express an inducible form of nitric oxide synthase and produce NO in response to inflammatory cytokines and activated T cells. Immunology 83:404–409PubMedGoogle Scholar
  19. Mandai M, Yoshimura N, Yoshida M, Iwaki M, Honda Y (1994) The role of nitric oxide synthase in endotoxin-induced uveitis: effect of N G-nitro-L-arginine. Invest Ophthalmol Vis Sci 35:3673–3681PubMedGoogle Scholar
  20. Martin E, Nathan C, Xie Q (1994) Role of interferon regulatory factor 1 in induction of nitric oxide synthase. J Exp Med 180:977–984PubMedCrossRefGoogle Scholar
  21. Nathan CF, Xie Q (1994) Nitric oxide synthases: roles, tolls, and controls. Cell 78:915–918PubMedCrossRefGoogle Scholar
  22. Nüssler AK, Billiar TR (1993) Inflammation, immunoregulation, and inducible nitric oxide synthase. J Leukoc Biol 54:171–178PubMedGoogle Scholar
  23. Parks DJ, Cheung MK, Chan CC, Roberge FG (1994) The role of nitric oxide in uveitis. Arch Ophthalmol 112:544–546PubMedGoogle Scholar
  24. Shuai K (1994) Interferon-activated signal transduction to the nucleus. Curr Opin Cell Biol 6:253–259PubMedCrossRefGoogle Scholar
  25. Sparrow JR, Nathan CF, Vodovotz Y (1994) Cytokine regulation of nitric oxide synthase in mouse retinal pigment epithelial cells in culture. Exp Eye Res 59:129–139PubMedCrossRefGoogle Scholar
  26. Ulevitch RJ, Tobias PS (1994) Recognition of endotoxin by cells leading to transmembrane signaling. Curr Opin Cell Biol 6:125–130Google Scholar
  27. Xie Q, Kashiwabara Y, Nathan C (1994) Role of transcription factor NFKB/Rel induction of nitric oxide synthase. J Biol Chem 269:4705–4708PubMedGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 2000

Authors and Affiliations

  • Olivier Goureau
    • 1
  • Violaine Faure
    • 1
  • Yvonne De Kozak
    • 2
  • Francine Behar-Cohen
    • 1
  • Pablo Dighiero
    • 1
  • Yves Courtois
    • 1
  1. 1.Développement, Vieillissement et Pathologie de la RétineINSERM U450ParisFrance
  2. 2.Laboratoire d’Immunopathologie OculaireINSERM U86Paris 06France

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