Abstract
The aim of this chapter is to describe the effect of nitric oxide (NO) on the iris sphincter muscle. NO is a labile free radical, and it has a role as a neurotransmitter as well (Moncada et al. 1991; Grozdanovic et al. 1994). Studies have demonstrated that NO relaxes various kinds of smooth muscles, including those of the respiratory (Sekizawa et al. 1993), digestive (Stark and Szurszewski 1992; Wiklund et al. 1993), genitourinary (Persson and Andersson 1992; Ehren et al. 1994), and vascular (Moncada et al. 1991) systems. There are few reports in terms of the effect of NO on the iris sphincter muscle. We have already clarified the effect of NO on the rabbit iris sphincter muscle for the first time (Chuman et al. 1996, 1997); here we summarize the effect of NO on the iris sphincter muscle (Fig. 1). We noted in rabbits that, the increased accumulation of cyclic guanosine monophosphate (cGMP) induced by sodium nitroprusside (SNP) (an NO donor) in the iris sphincter muscle inhibits cholinergic muscular contraction but does not affect tachykinergic muscular contraction. These results suggest that the different effects on cGMP are essential for the different responses to NO in cholinergic and tachykinergic muscular contractions. Furthermore, this NO-cGMP pathway is operative in vivo for the modulation of iris sphincter muscle tone, at least when the eyes are infected with bacteria.
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References
Abdel-Latif AA (1989) Calcium-mobilizing receptors, polyphosphoinositides, generation of second messengers and contraction in the mammalian iris smooth muscle: historical perspectives and current status. Life Sci 45:757–786
Abdel-Latif AA (1997) Iris-ciliary body, aqueous humor and trabecular meshwork. In: Harding JJ (ed) Biochemistry of the eye. Chapman & Hall, London, pp 79
Ahlner J, Andersson RGG, Torfgard K, Axelsson KL (1991) Organic nitrate esters: clinical use and mechanisms of actions. Pharmacol Rev 43:351–423
Astin M, Stjernschntz J, Selen G (1994) Role of nitric oxide in PGF2alPha-induced ocular hyperemia. Exp Eye Res 59:401–407
Bolotina VM, Najibi S, Palacino JJ, Pagano PJ, Cohen RA (1994) Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle. Nature 368:850–853
Chuman H, Chuman T, Nao-i N, Sawada A, Yamamoto R, Kobayashi H, Wada A (1997) Different responsiveness to nitric oxide-cyclic guanosine monophosphate pathway in cholinergic and tachykinergic contractions of the rabbit iris sphincter muscle. Invest Ophthalmol Vis Sci 38:1719–1725
Chuman T, Chuman H, Nao-i N, Sawada A, Yamamoto R, Wada A (1996) Nitric oxide-sensitive and-insensitive contractions of the isolated rabbit iris sphincter muscle. Invest Ophthalmol Vis Sci 37:1437–1443
Ding KH, Abdel-Latif AA (1997) Actions of C-type natriuretic peptide and sodium nitroprusside on carbachol-stimulated inositol phosphate formation and contraction in ciliary and iris sphincter smooth muscles. Invest Ophthalmol Vis Sci 38:2629–2638
Ehren I, Iversen H, Jansson O, Adolfsson J, Wiklund NP (1994) Localization of nitric oxide synthase activity in the human lower urinary tract and its correlation with neuroeffec-tor responses. Urology 44:683–687
Grozdanovic Z, Brüning G, Baumgarten HG (1994) Nitric oxide: a novel autonomic neurotransmitter. Acta Anat (Basel) 150:16–24
Hogan MJ, Alvalado JA, Weddel JE (1971) Histology of the human eye. Philadelphia, Saunders
Hope BT, Michael GJ, Knigge KM, Vincent SR (1991) Neuronal NADPH diaphorase is a nitric oxide synthase. Proc Natl Acad Sci USA 88:2811–2814
Ignaro LJ (1991) Signal transduction mechanisms involving nitric oxide. Biochem Pharmacol 41:485–490
Jacquemin E, Kozak YD, Thillaye B, Courtois Y, Goureau O (1996) Expression of inducible nitric oxide synthase in the eye from endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci 37:1187–1196
Jerusalinsky D, Harvey AL (1994) Toxins from mamba venoms: small proteins with selectivites for different subtypes of muscarinic acetylcholine receptors. Trends Pharmacol Sci 15 (11):424–430
Mandai M, Yoshimura N, Yoshida M, Iwaki M, Honda Y (1994) The role of nitric oxide synthase in endotoxin-induced uveitis: effects of N G-nitro-L-arginine. Invest Ophthalmol Vis Sci 35:3673–3680
Moncada S, Higgs A (1993) The L-arginine-nitric oxide pathway. N Engl J Med 329:2002–2012
Moncada S, Palmer RMJ, Higgs EA (1991) Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43:109–142
Osborne NN, Barnett NL, Herrera AJ (1993) NADPH diaphorase localization and nitric oxide synthetase activity in the retina and anterior uvea of the rabbit eye. Brain Res 610:194–198
Persson K, Andersson KE (1992) Nitric oxide and relaxation of pig lower urinary tract. Br J Pharmacol 106:416–422
Regoli D, Boudon A, Fauchére JL (1994) Receptors and antagonists for substance P and related peptides. Pharmacol Rev 46:551–599
Sekizawa K, Fukushima T, Ikarashi Y, Maruyama Y, Sasaki H (1993) The role of nitric oxide in cholinergic neurotransmission in rat trachea. Br J Pharmacol 110:816–820
Smith SS, Li J (1993) Novel action of nitric oxide as mediator of N-methyl-D-aspartate-induced phosphatidylinositol hydrolysis in neonatal rat cerebellum. Mol Pharmacol 43:1–5
Stark ME, Szurszewski JH (1992) Role of nitric oxide in gastrointestinal and hepatic function and disease. Gastroenterology 103:1928–1949
Tachado SD, Akhtar RA, Yousufzai SYK, Abdel-Latif AA (1991) Species differences in the effects of substance P on inositol trisphosphate accumulation and cyclic AMP formation, and on contraction in isolated iris sphincter of the mammalian eye: differences in receptor density. Exp Eye Res 53:729–739
Taniguchi T, Ninomiya H, Fukunaga R, Ebii K, Yamamoto M, Fujiwara M (1992) Neurokinin A-stimulated phosphoinositide breakdown in rabbit iris sphincter muscle. Jpn J Pharmacol 59:213–220
Ueda N, Muramatsu I, Sakakibara Y, Fujiwara M (1981) Noncholinergic, nonadrenergic contraction and substance P in rabbit iris sphincter muscle. Jpn J Pharmacol 31:1071–1079
Wess J (1993) Molecular basis of muscarinic acetylcholine receptor function. Trends Pharmacol Sci 14:308–313
Wiklund CU, Olgart C, Wiklund NP, Gustafsson LE (1993) Modulation of cholinergic and substance P-like neurotransmission by nitric oxide in the guinea-pig ileum. Br J Pharmacol 110:833–839
Wiklund CU, Wiklund NP, Gustafsson LE (1993) Modulation of neuroeffector transmission by endogenous nitric oxide: a role for acetylcholine receptor-activated nitric oxide formation, as indicated by measurements of nitric oxide/nitrite release. Eur J Pharmacol 240:235–242
Yamamoto R, Bredt DS, Snyder SH, Stone RA (1993) The localization of nitric oxide synthase in the rat eye and related cranial ganglia. Neuroscience 54:189–200
Yousufzai SY, Abdel-latif AA (1997) Nitric oxide-prostaglandin interactions. Biochemistry of the eye 78–79
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Chuman, H., Chuman, T. (2000). Nitric Oxide in the Iris Sphincter Muscle. In: Kashii, S., Akaike, A., Honda, Y. (eds) Nitric Oxide in the Eye. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67949-3_6
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DOI: https://doi.org/10.1007/978-4-431-67949-3_6
Publisher Name: Springer, Tokyo
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