Regulation of Retinal Arterial and Arteriolar Tone by Nitric Oxide Derived from Endothelium and Perivascular Nerve

  • Noboru Toda
  • Megumi Toda
  • Tomio Okamura


Nitric oxide (NO) is now recognized to be a key substance for regulating functions of not only the cardiovascular, nervous, and immune systems but also other organs and tissues of almost the entire body. The role of NO derived from the endothelium and perivascular nerve has not been well understood in the ocular circulation, possibly because detailed analyses in in vitro studies are difficult in such a small and fragile ocular artery. This chapter describes the role of endothelium-derived NO in isolated retinal central arteries and retinal arterioles in vivo. It also describes the role of NO derived from perivascular nerve in isolated retinal central, ophthalmic, and cerebral arteries and the retinal arterioles in vivo.


Nitric Oxide Methylene Blue Vasoactive Intestinal Peptide Ophthalmic Artery Ocular Blood Flow 
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Copyright information

© Springer-Verlag Tokyo 2000

Authors and Affiliations

  • Noboru Toda
    • 1
    • 2
  • Megumi Toda
    • 1
  • Tomio Okamura
    • 1
  1. 1.Department of PharmacologyShiga University of Medical ScienceSeta, OhtsuJapan
  2. 2.Toyama Institute for Cardiovascular Pharmacology ResearchAzuchi-machi, Chuo-ku, OsakaJapan

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