Contractility of Trabecular Meshwork and Ciliary Muscle: Modulation by the NO/cGMP System
Data indicate that nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) can function as an intracellular signal transduction system. If specific cells contain both nitric oxide synthase (NOS) and guanylate cyclase activated by NO, intracellular cGMP can be regulated by substances that alter NOS activity and NO formation (Moncada et al. 1991; Moncada 1992; Nathan 1992).
KeywordsNitric Oxide Trabecular Meshwork Contractile Property Nonselective Cation Channel Isosorbide Dinitrate
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